3-{1-[(3-phenylmorpholin-4-yl)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine | 1207611-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-{1-[(3-phenylmorpholin-4-yl)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridine
• 英文别名: (3-phenylmorpholin-4-yl)-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methanone
• CAS: 1207611-81-1
• 化学式: C₂₃H₂₄N₄O₂
• 分子量: 388.469
• InChiKey: PZSXSIXOQRMBMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  61.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Vasudevan Anil

  公开号：US20100035919A1

  公开（公告）日：2010-02-11

  Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein A, X 1 , X 2 , R 1 , R 2 , R 3 , m, n, and p are defined in the specification. Compositions including the compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using the compositions are also described.

  本文披露了式（I）的化合物或其药用可接受的盐，其中A、X1、X2、R1、R2、R3、m、n和p在规范中有定义。还描述了包括这些化合物的组合物，这些组合物可用于抑制Rho激酶（ROCK），并描述了使用这些组合物的方法。
• [EN] COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES<br/>[FR] COMPOSÉS UTILES COMME INHIBITEURS DE PROTÉINE KINASES
  申请人：ABBOTT LAB

  公开号：WO2010017150A1

  公开（公告）日：2010-02-11

  Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein A, X1, X2, R1, R2, R3, m, n, and p are defined in the specification. Compositions including the compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using the compositions are also described.