4-[Ethyl(methyl)amino]but-2-enoic acid hydrochloride | 1449501-61-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-[Ethyl(methyl)amino]but-2-enoic acid hydrochloride
• 英文别名: (E)-4-[ethyl(methyl)amino]but-2-enoic acid;hydrochloride
• CAS: 1449501-61-4
• 化学式: C7H14ClNO2
• 分子量: 179.64
• InChiKey: FLMGUUBHCFKZIW-FXRZFVDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.0
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL QUINOLINE -SUBSTITUTED COMPOUND
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20160194332A1

  公开（公告）日：2016-07-07

  An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as a medication useful for the prevention and/or treatment of cancer based on the EGFR inhibitory effects. The present invention provides a compound represented by Formula (I) below, or a salt thereof.

  本发明的目标是提供一种具有EGFR抑制作用和细胞生长抑制作用的新化合物，以及一种基于EGFR抑制作用的用于预防和/或治疗癌症的药物。本发明提供以下式（I）所代表的化合物或其盐。
• PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR IMMUNE DISEASES
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3120852A1

  公开（公告）日：2017-01-25

  Provided is a preventive and/or therapeutic agent for immune diseases containing a compound having a BTK inhibitory activity or a salt thereof, as an active ingredient. A preventive and/or therapeutic agent of immune diseases, comprising a compound represented by Formula (I), where R1 to R3, W, X, Y, Z, and n represent those as defined in the specification, or a salt thereof, as an active ingredient.

  本发明提供了一种免疫疾病的预防和/或治疗剂，其活性成分包含一种具有 BTK 抑制活性的化合物或其盐。 一种免疫疾病的预防和/或治疗剂，包含由式（I）代表的化合物（其中 R1 至 R3、W、X、Y、Z 和 n 代表说明书中定义的那些）或其盐作为活性成分。
• NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP3486244A1

  公开（公告）日：2019-05-22

  The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.

  本发明涉及一种具有 FGFR 抑制活性的新化合物及其制备和应用。特别是，根据本发明的化合物具有如式 I 所示的结构，其中各基团和取代基如描述中所定义。本发明还公开了该化合物的制备方法及其在制备治疗和/或预防肿瘤相关疾病和/或FGFR相关疾病的药物中的用途。
• NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP2947086B1

  公开（公告）日：2018-01-03
• PREVENTIVE AND/OR THERAPEUTIC AGENT FOR IMMUNE DISEASES
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3120852B1

  公开（公告）日：2019-05-01