methyl 4-(4-chlorophenyl)-1-(4-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxylate | 1456965-32-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 4-(4-chlorophenyl)-1-(4-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxylate
• CAS: 1456965-32-4
• 化学式: C₂₀H₁₈ClNO₃
• 分子量: 355.821
• InChiKey: GWJDOCSHVAKTIU-UHFFFAOYSA-N

物化性质

• 沸点：
  500.2±50.0 °C(predicted)
• 密度：
  1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  硝基甲烷 、 4-氯苯甲醛 、 甲氧苯胺 、 乙酰乙酸甲酯 在 silica tungstic acid 作用下， 反应 4.17h， 以82%的产率得到methyl 4-(4-chlorophenyl)-1-(4-methoxyphenyl)-2-methyl-1H-pyrrole-3-carboxylate
  参考文献：
  名称：

  Heterogenized tungsten complex: an efficient and high yielding catalyst for the synthesis of structurally diverse tetra substituted pyrrole derivatives via four-component assembly

  摘要：

  An efficient, high yielding, and expeditious method has been developed for the synthesis of diversity oriented pyrrole derivatives via a four component, one-pot cyclocondensation reaction of amines, aldehydes, alpha-methylene ketones, and nitroalkanes using silica supported tungstic acid as a heterogeneous catalyst for the first time. The scope of the domino reaction is successfully explored toward synthesis of highly aryl-substituted pyrroles. The reaction was conveniently promoted by silica supported tungstic acid and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.016