Ethyl 3-amino-2-(2,4-dichlorophenyl)-1,5-dimethylpyrrole carboxylate | 389796-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Ethyl 3-amino-2-(2,4-dichlorophenyl)-1,5-dimethylpyrrole carboxylate
• 英文别名: Ethyl 4-amino-5-(2,4-dichlorophenyl)-1,2-dimethylpyrrole-3-carboxylate
• CAS: 389796-31-0
• 化学式: C₁₅H₁₆Cl₂N₂O₂
• 分子量: 327.21
• InChiKey: CSMAGDNISQZDQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
  申请人：——

  公开号：US20020022632A1

  公开（公告）日：2002-02-21

  Corticotropin releasing factor (CRF) antagonists of Formula (I) or (II) 1 and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

  Corticotropin Releasing Factor (CRF)拮抗剂公式(I)或(II)1及其在治疗焦虑、抑郁和其他精神、神经疾病方面的使用，以及治疗与心理病理障碍和压力相关的免疫、心血管或心脏疾病和结肠过敏反应。
• PYRROLO 3,4-d]PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1301513A2

  公开（公告）日：2003-04-16
• US6630476B2
  申请人：——

  公开号：US6630476B2

  公开（公告）日：2003-10-07
• US6734185B2
  申请人：——

  公开号：US6734185B2

  公开（公告）日：2004-05-11
• [EN] PYRROLO[3,4-d]PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS<br/>[FR] PYRROLO[3,4-D]PYRIMIDINES COMME ANTAGONISTES DE LA CORTICOLIBERINE (CRF)
  申请人：DU PONT PHARM CO

  公开号：WO2002004453A2

  公开（公告）日：2002-01-17

  Corticotropin releasing factor (CRF) antagonists of Formula (I) or (II) and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.