5-amino-3-(2',3'-dideoxy-β-D-ribofuranosyl)-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione | 892499-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-amino-3-(2',3'-dideoxy-β-D-ribofuranosyl)-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione
• 英文别名: 5-amino-3-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-6H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione
• CAS: 892499-82-0
• 化学式: C₁₀H₁₂N₄O₄S
• 分子量: 284.296
• InChiKey: CNVWRPUOBMRBSJ-CRCLSJGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-N-acetylamino-3-(2',3'-dideoxy-β-D-ribofuranosyl)-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione 在 甲醇 、 potassium carbonate 、 溶剂黄146 作用下， 反应 18.0h， 以36%的产率得到5-amino-3-(2',3'-dideoxy-β-D-ribofuranosyl)-3H,6H-thiazolo[4,5-d]pyrimidine-2,7-dione
  参考文献：
  名称：

  WO2006/66080

  摘要：

  公开号：

文献信息

• PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY
  申请人：Cannizzaro Carina

  公开号：US20090227543A1

  公开（公告）日：2009-09-10

  The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷酸酯取代化合物，具有免疫调节活性，含有这种化合物的组合物，以及包括这种化合物的给药的治疗方法，还涉及用于制备这种化合物的有用过程和中间体。
• 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof
  申请人：Averett Devron R.

  公开号：US20080070852A1

  公开（公告）日：2008-03-20

  The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

  本发明涉及3-β-D-核糖呋喃基噻唑[4,5-d]嘧啶核苷及含有这种化合物的药物组合物，其具有免疫调节活性。本发明还涉及使用这种化合物和组合物进行治疗或预防，以及通过给予有效剂量的这种化合物来治疗本文所述的疾病和障碍的方法。
• METHODS FOR THE PREPARATION OF IMIDAZOLE-CONTAINING COMPOUNDS
  申请人：Valiante Nicholas M.

  公开号：US20100010217A1

  公开（公告）日：2010-01-14

  The present invention generally relates to methods for the preparation of compounds that contain imidazole moieties. In some embodiments, the methods include the reaction of a diamine with a dichloroimmonium compound to produce the imidazole moiety. In some embodiments, the methods are employed to prepare compounds having the Formulas II, II or III below: I II III wherein the constituent variables are as described herein.

  本发明通常涉及制备含咪唑基团的化合物的方法。在某些实施例中，该方法包括将二胺与二氯咪唑化合物反应以产生咪唑基团。在某些实施例中，该方法用于制备具有以下公式II，II或III的化合物：I II III，其中组分变量如本文所述。
• 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
  申请人：Averet Devron R.

  公开号：US20080255063A1

  公开（公告）日：2008-10-16

  The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

  本发明涉及3-β-D-核糖呋喃噻唑并[4,5-d]嘧啶核苷及含有这种化合物的制药组合物，该化合物具有免疫调节活性。本发明还涉及使用这种化合物和组合物的治疗或预防用途，以及通过给予有效剂量的这种化合物来治疗本文所述的疾病和障碍的方法。
• IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS
  申请人：Sutton James

  公开号：US20090311288A1

  公开（公告）日：2009-12-17

  The invention proyides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent (s).

  该发明提供了包含公式(I)及其类似物的咪唑喹啉化合物的新型组合物。还提供了将该组合物以有效剂量给予受试者以增强其免疫反应的方法。此外，还提供了新型组合物和将其与（一种）其他药剂（S）一起给予的方法。