(3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one | 882172-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one
• CAS: 882172-39-6
• 化学式: C₂₀H₂₁NO
• 分子量: 291.393
• InChiKey: UPAZCGBWAHKSFM-IEBWSBKVSA-N

反应信息

• 作为反应物：
  描述：

  (3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one 在 盐酸 作用下， 反应 24.0h， 以100%的产率得到(R)-2-Benzyl-4-(R)-1,2,3,4-tetrahydro-isoquinolin-3-yl-butyric acid
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005
• 作为产物：
  描述：

  2,2-Dimethyl-5-[(R)-2-(1,2,3,4-tetrahydro-isoquinolin-3-yl)-ethyl]-[1,3]dioxane-4,6-dione 在 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 6.0h， 生成 (3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one
  参考文献：
  名称：

  Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists

  摘要：

  The first synthesis of Tic-D-Phe Psi[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.005