3,3-Dimethyl-5-(methylamino)-5-oxopentanoic acid | 716362-45-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3,3-Dimethyl-5-(methylamino)-5-oxopentanoic acid
• CAS: 716362-45-7
• 化学式: C₈H₁₅NO₃
• 分子量: 173.21
• InChiKey: IGBMLFKRRFBZOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Inhibition of Hiv-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein
  申请人：Salzwedel Karl

  公开号：US20080200550A1

  公开（公告）日：2008-08-21

  Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to Gag rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.

  抑制HIV-1繁殖的方法是通过破坏病毒Gag外壳蛋白（CA）蛋白（p24）从CA-间隔肽1（SP1）蛋白前体（p25）的处理来实现的。包括含有Gag p25蛋白中突变的氨基酸序列，该突变导致二甲基琥珀酰基齐墩果酸或二甲基琥珀酰基齐墩的p25到p24处理的抑制减少，编码这种突变序列的多核苷酸和选择性结合这种突变序列的抗体。还包括抑制方法、抑制化合物和发现靶向HIV Gag蛋白的蛋白酶解处理的抑制化合物的方法。在其中一种实施例中，这些化合物通过与Gag结合而不是与蛋白酶酶结合来抑制HIV蛋白酶酶与Gag的相互作用。在另一种实施例中，包含在Gag蛋白酶解割位区域中的突变病毒或重组蛋白可以用于筛选测定，以识别靶向蛋白酶解处理的化合物。
• Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein
  申请人：SALZWEDEL Karl

  公开号：US20080233559A1

  公开（公告）日：2008-09-25

  Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to Gag rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.

  本文揭示了通过破坏病毒Gag外壳蛋白（CA）从CA-spacer肽1（SP1）蛋白前体（p25）中的处理来抑制HIV-1复制的方法。包括含有Gag p25蛋白中突变的氨基酸序列，该突变导致二甲基琥珀酰基白桦酸或二甲基琥珀酰基白桦醇对p25到p24的处理抑制减少，编码这种突变序列的多核苷酸以及选择性结合这种突变序列的抗体。还包括抑制，抑制性化合物和发现靶向HIV Gag蛋白的蛋白酶加工的抑制性化合物的方法。在一种实施方式中，这些化合物通过结合Gag而不是蛋白酶酶来抑制HIV蛋白酶酶与Gag的相互作用。在另一种实施方式中，包含在Gag蛋白酶剪切位点区域中的突变病毒或重组蛋白可以用于筛选测定，以识别靶向蛋白酶加工的化合物。
• POLYMER COMPOSITIONS AND METHODS
  申请人：SAUDI ARAMCO TECHNOLOGIES COMPANY

  公开号：EP2707224B1

  公开（公告）日：2017-10-25
• US7537765B2
  申请人：——

  公开号：US7537765B2

  公开（公告）日：2009-05-26
• US7645771B2
  申请人：——

  公开号：US7645771B2

  公开（公告）日：2010-01-12