Methyl 6-nitrosohexanoate | 38167-92-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 6-nitrosohexanoate
• CAS: 38167-92-9
• 化学式: C₇H₁₃NO₃
• 分子量: 159.18
• InChiKey: RFIKBJRFAOCGQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  55.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Method of producing nylon
  申请人：Evonik Degussa GmbH

  公开号：EP2944697A1

  公开（公告）日：2015-11-18

  There is provided a method of producing aminohexanoic acid and/or aminohexanoic acid ester from synthesis gas, the method comprising: - contacting the synthesis gas with at least one acetogenic bacteria and/or hydrogen oxidising bacteria to produce hexanoic acid; - contacting the hexanoic acid with C1-C4 alcohol to produce C1-C4 hexanoate; contacting the C1-C4 hexanoate with a genetically modified cell to produce aminohexanoic acid and/or aminohexanoic acid ester, wherein the genetically modified cell has an increased activity, in comparison with its wild type, in enzymes, alkane monooxygenase, alcohol dehydrogenase, and/or ω-transaminase.

  提供了一种利用合成气生产氨基己酸和/或氨基己酸酯的方法，该方法包括 - 将合成气与至少一种产乙酸细菌和/或氢氧化细菌接触，生成己酸； - 将己酸与 C1-C4 醇接触，生成 C1-C4 己酸酯；将 C1-C4 己酸酯与转基因细胞接触，生成氨基己酸和/或氨基己酸酯，其中转基因细胞与野生型相比，在酶、烷烃单加氧酶、醇脱氢酶和/或ω-反式胺酶方面具有更高的活性。
• Modified iRNA agents
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US10676740B2

  公开（公告）日：2020-06-09

  The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety. e.g., cholesterol, is is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.

  本发明涉及 iRNA 制剂，它最好包括一种单体，其中的核糖分子已被核糖以外的分子所取代。 加入这种单体可以调节加入其中的 iRNA 制剂的性质，例如，通过使用非核糖分子作为配体或其他实体（如亲脂分子，如胆固醇）直接或间接的连接点。 本发明还涉及制造和使用这种改性 iRNA 制剂的方法。
• METHOD OF PRODUCING NYLON
  申请人：Evonik Degussa GmbH

  公开号：EP3143151A1

  公开（公告）日：2017-03-22
• Method of Producing Nylon
  申请人：Evonik Degussa GmbH

  公开号：US20170260553A1

  公开（公告）日：2017-09-14

  There is provided a method of producing aminohexanoic acid and/or aminohexanoic acid ester from synthesis gas, the method comprising: A. contacting the synthesis gas with at least one bacteria capable of carrying out the Wood-Ljungdahl pathway and the ethanol-carboxylate fermentation to produce hexanoic acid; and B. contacting the hexanoic acid with a genetically modified cell to produce aminohexanoic acid and/or aminohexanoic acid ester, wherein the genetically modified cell has an increased activity, in comparison with its wild type, of alkane monooxygenase, alcohol dehydrogenase, and ω-transaminase.
• [EN] METHOD OF PRODUCING NYLON<br/>[FR] PROCÉDÉ DE PRODUCTION DE NYLON
  申请人：EVONIK DEGUSSA GMBH

  公开号：WO2015173059A1

  公开（公告）日：2015-11-19

  There is provided a method of producing aminohexanoic acid and/or aminohexanoic acid ester from synthesis gas, the method comprising: A. contacting the synthesis gas with at least one bacteria capable of carrying out the Wood- Ljungdahl pathway and the ethanol-carboxylate fermentation to produce hexanoic acid; and B. contacting the hexanoic acid with a genetically modified cell to produce aminohexanoic acid and/or aminohexanoic acid ester, wherein the genetically modified cell has an increased activity, in comparison with its wild type, of alkane monooxygenase, alcohol dehydrogenase, and ω-transaminase.