1-(3-Methyl-3-pentyl)hydantoin | 54508-46-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(3-Methyl-3-pentyl)hydantoin
• 英文别名: 1-(1-ethyl-1-methyl-propyl)-imidazolidine-2,4-dione；1-(3-Methylpentan-3-yl)imidazolidine-2,4-dione
• CAS: 54508-46-2
• 化学式: C₉H₁₆N₂O₂
• 分子量: 184.238
• InChiKey: KDLGKAWWJNKRKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20170158628A1

  公开（公告）日：2017-06-08

  The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.
• US9790173B2
  申请人：——

  公开号：US9790173B2

  公开（公告）日：2017-10-17