2-hydroxytriacontanoic acid | 122751-79-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxytriacontanoic acid
• CAS: 122751-79-5
• 化学式: C₃₀H₆₀O₃
• 分子量: 468.805
• InChiKey: FOPDLHYJCVRBAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14
• 重原子数：
  33
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOSITIONS COMPRISING POLYMERS PREPARED FROM 2-HYDROXYALKYL ACIDS
  申请人：Moeller Michael

  公开号：US20130131190A1

  公开（公告）日：2013-05-23

  Described herein are compositions comprising polymers prepared by melt polycondensation of 2-hydroxyalkyl acids. Methods of making and using the compositions are also disclosed.

  本文描述了由2-羟基烷基酸熔融缩聚制备的聚合物组成物。还公开了制备和使用该组成物的方法。
• Refrigerator oil composition
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0802254A1

  公开（公告）日：1997-10-22

  Disclosed is a refrigerator oil composition comprising at least one base oil selected from mineral oils and synthetic oils, and at least one hydroxy-fatty acid derivative selected from (A) hydroxy-fatty acids or their condensates, (B) metal salts or amine salts of hydroxy-fatty acids or their condensates, and (C) esters of hydroxy-fatty acids. The composition has an excellent lubricating property, while specifically improving the lubricity between aluminium materials and steel materials. This is effective for preventing such materials from being seized and worn, and is suitable as a lubricating oil in refrigerators using hydrogen-containing Flon refrigerants, such as R134a, that do not cause environmental pollution.

  本发明公开了一种冷冻机油组合物，该组合物包含至少一种选自矿物油和合成油的基础油，以及至少一种选自 (A) 羟基脂肪酸或其缩合物、(B) 羟基脂肪酸或其缩合物的金属盐或胺盐，以及 (C) 羟基脂肪酸酯的羟基脂肪酸衍生物。该组合物具有极佳的润滑性能，尤其能改善铝材料和钢材料之间的润滑性。这可有效防止此类材料卡死和磨损，适用于使用不会造成环境污染的含氢氟隆制冷剂（如 R134a）的冰箱的润滑油。
• RESIN COMPOSITION
  申请人：ZEON CORPORATION

  公开号：EP1712594A1

  公开（公告）日：2006-10-18

  A resin composition includes an alicyclic structure-containing polymer; a hindered amine compound; and a releasing agent, wherein the releasing agent and the alicyclic structure-containing polymer satisfy the following relationship: 10 ≥ |s1-s2| ≥ 0.8 [(MPa)0.5], wherein s1 represents a solubility parameter of the releasing agent, and s2 represents a solubility parameter of the alicyclic structure-containing polymer. The resin composition can be used as optical materials, such as a lens, a diffraction grating, and a prism, especially in the field of using blue laser, and has excellent releasability, transparence and colorless property as well as excellent resistance to laser.

  一种树脂组合物包括含脂环结构聚合物、受阻胺化合物和脱模剂，其中脱模剂和含脂环结构聚合物满足以下关系：10≥|s1-s2|≥0.8[(MPa)0.5]，其中 s1 代表释放剂的溶解度参数，s2 代表含脂环结构聚合物的溶解度参数。该树脂组合物可用作透镜、衍射光栅和棱镜等光学材料，特别是在使用蓝色激光的领域，具有出色的可释放性、透明性和无色性，以及出色的耐激光性。
• 8-ARM POLYETHYLENE GLYCOL DERIVATIVE, MANUFACTURING METHOD AND MODIFIED BIO-RELATED SUBSTANCE THEREBY
  申请人：Xiamen Sinopeg Biotech Co., Ltd.

  公开号：EP3315531A1

  公开（公告）日：2018-05-02

  Disclosed are an 8-arm polyethylene glycol (PEG) derivative (formula 1), manufacturing method and modified bio-related substance thereby, wherein a tetravalent group U and four trivalent groups Ec form a highly symmetric octavalent central structure CORE0 together, Lc connects the octavalent center to eight PEG arms having polydiversity or monodiversity and having n1-n8 as the degrees of polymerization thereof. The terminal of one PEG chain is connected to at least one functional group F (k ≥ 1), and said PEG chain and F can be directly connected (g = 0) or connected with a divalent linking group L0 connected with a terminal branched group G (g = 1) therebetween. The latter provides more reacting sites to combine more pharmaceutical molecules, thereby increasing the drug loading capacity. The near-center symmetric structure of the derivative allows more precise control over the molecular weight during large-scale production, thereby facilitating acquisition of a product having a narrower molecular weight distribution. A bio-related substance modified thereby has a more uniform and controllable performance.

  本发明公开了一种 8 臂聚乙二醇（PEG）衍生物（式 1）、其制造方法和改性生物相关物质，其中一个四价基团 U 和四个三价基团 Ec 共同形成一个高度对称的八价中心结构 CORE0，Lc 将八价中心连接到八个 PEG 臂上，这些 PEG 臂具有多元性或单元性，其聚合度为 n1-n8。一条 PEG 链的末端与至少一个官能团 F（k ≥ 1）相连，所述 PEG 链和 F 可以直接相连（g = 0），也可以通过二价连接基 L0 与中间的末端支化基 G（g = 1）相连。后者提供了更多的反应位点，可以结合更多的药物分子，从而提高药物负载能力。衍生物的近中心对称结构可以在大规模生产过程中更精确地控制分子量，从而有利于获得分子量分布更窄的产品。由此改性的生物相关物质具有更均匀、更可控的性能。
• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。