tert-butyl 2-(3-ethynylphenoxyl)ethylcarbamate | 1098107-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl 2-(3-ethynylphenoxyl)ethylcarbamate
• 英文别名: tert-Butyl (2-(3-ethynylphenoxy)ethyl)carbamate；tert-butyl N-[2-(3-ethynylphenoxy)ethyl]carbamate
• CAS: 1098107-28-8
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: KNRCWCHUBYIQEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(3-ethynylphenoxyl)ethylcarbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-(3-ethynylphenoxy)ethanamine
  参考文献：
  名称：

  Chemically Fueled Communication Along a Scaffolded Nanoscale Array of Squaramides

  摘要：

  摘要在几个纳米的范围内实现构象变化是异位调节蛋白功能的核心。人工复制这种机制将提供重要的通信工具，但需要纳米级的分子能在确定的形状之间可逆地切换，以响应信号分子。在这项研究中，1.8 纳米长的硬棒寡（苯乙炔）是可切换的多夸酰胺氢键中继的支架。相对于支架，每个中继体可以采用平行或反平行取向；首选取向由一端的导向基决定。一个胺引导基团对质子信号做出反应，酸碱循环产生多个可逆的中继方向变化，距离 1.8 纳米的末端 NH 报告了这些变化。此外，化学燃料也起着耗散信号的作用。随着燃料的消耗，中继器恢复到原来的方向，这说明了失衡分子信号的信息是如何传递到遥远的位置的。

  DOI：

  10.1002/anie.202307841
• 作为产物：
  描述：

  在 甲醇 、 potassium carbonate 作用下， 反应 1.5h， 生成 tert-butyl 2-(3-ethynylphenoxyl)ethylcarbamate
  参考文献：
  名称：

  Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA

  摘要：

  Peptide nucleic acids (PNA) containing meta-substituted 6-phenylpyrrolocytosine (PhpC), [mono-m)-(aminoethoxy)phenyl]pyrrolocytosine (mmePhpC), [mono-m-(aminopropoxy)phenyl]pyrrolocytosine (mmpPhpC), and [mono-m-(guanidinoethoxy)phenyl]pyrrolocytosine (mmguaPhpC), have been synthesized. Meta-substituted PhpCs have been hybridized with overall higher binding affinity toward DNA and RNA than previously synthesized moePhpC or newly synthesized mopPhpC. The guanidinium-containing nucleobase, mmguaPhpC, exhibited the highest increase in binding affinity toward RNA while fluorometrically responding on the state of hybridization.

  DOI：

  10.1021/ol9019474

文献信息

• Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
  申请人：Scott Ian Leslie

  公开号：US20090062353A1

  公开（公告）日：2009-03-05

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物，其药物组成物及使用该化合物和组成物治疗眼科疾病和疾患的方法，例如老年性黄斑变性和斯塔格特病。
• Amine Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Scott Ian L.

  公开号：US20090281149A1

  公开（公告）日：2009-11-12

  Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明涉及一种胺衍生物化合物，其制备的药物组合物以及使用该化合物和组合物治疗眼科疾病和障碍的方法，例如老年性黄斑变性和Stargardt病。
• AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian L.

  公开号：US20120041038A1

  公开（公告）日：2012-02-16

  Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了氨基衍生物化合物、其制药组合物以及使用所述化合物和组合物治疗眼科疾病和疾患的方法，例如老年性黄斑变性和Stargardt病。
• Alkynyl Phenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Scott Ian Leslie

  公开号：US20120004269A1

  公开（公告）日：2012-01-05

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物、其制药组合物以及使用该化合物和组合物治疗眼科疾病和障碍的方法，例如老年性黄斑变性和Stargardt病。
• ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian Leslie

  公开号：US20130018077A1

  公开（公告）日：2013-01-17

  Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了炔基苯衍生物化合物、其制药组合物以及使用该化合物和组合物治疗眼科疾病和疾病的方法，例如老年性黄斑变性和Stargardt病。