(4-Methoxymethyl-cyclohexyl)-acetic acid methyl ester | 1114554-27-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4-Methoxymethyl-cyclohexyl)-acetic acid methyl ester
• 英文别名: trans (4-Methoxymethyl-cyclohexyl)-acetic acid methyl ester；methyl 2-[4-(methoxymethyl)cyclohexyl]acetate
• CAS: 1114554-27-6
• 化学式: C₁₁H₂₀O₃
• 分子量: 200.278
• InChiKey: OXERFGPRWPSXFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-Methoxymethyl-cyclohexylidene)-acetic acid methyl ester 在 钯 作用下， 以 乙酸乙酯 为溶剂， 生成 (4-Methoxymethyl-cyclohexyl)-acetic acid methyl ester
  参考文献：
  名称：

  DUAL MODULATORS OF 5HT2A AND D3 RECEPTORS

  摘要：

  本发明涉及式(I)化合物，其中R1、R2、X和n如规范中定义的双重调节剂，作为血清素5-HT2a和多巴胺D3受体的治疗剂，它们的制造、含有它们的制药组合物以及治疗精神疾病、抑郁和焦虑症、药物依赖、痴呆症和记忆障碍等其他疾病的用途。

  公开号：

  US20120040972A1

文献信息

• BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS
  申请人：Gobbi Luca

  公开号：US20090042943A1

  公开（公告）日：2009-02-12

  The present invention relates to compounds of formula (I) wherein R 1 and A are as defined in the specification as dual modulators of the serotonin 5-HT 2a and dopamine D 3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D 3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT 2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

  本发明涉及以下式（I）的化合物 其中R 1 和A如说明书中定义的作为血清素5-HT 2a 和多巴胺D 3 受体的双调节剂，它们的制备，含有它们的药物组合物以及它们作为药物的用途。一般式（I）的化合物对多巴胺D 3 和血清素（5-羟色胺；5-HT）5-HT 2A 受体具有高亲和力，并且在治疗精神分裂症等疾病以及抑郁症、焦虑症、药物依赖、痴呆症和记忆障碍等其他疾病中具有有效性。
• DUAL MODULATORS OF 5HT2A AND D3 RECEPTORS
  申请人：Gobbi Luca

  公开号：US20090029977A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds of the formula (I) wherein R 1 , R 2 , X and n are as defined in the specification as dual modulators of the serotonin 5-HT 2a and dopamine D 3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

  本发明涉及公式（I）中R1、R2、X和n的化合物，其在说明书中被定义为5-HT2a和D3受体的双调节剂，它们的制备、含有它们的药物组合物以及它们用于治疗精神病性障碍以及其他疾病，如抑郁症、焦虑症、药物依赖、痴呆症和记忆障碍。
• Dual Modulators of 5HT2A and D3 Receptors
  申请人：Hoffmann-La Roche Inc.

  公开号：US20130165432A1

  公开（公告）日：2013-06-27

  The present invention relates to compounds of the formula (I) wherein R 1 , R 2 , X and n are as defined in the specification as dual modulators of the serotonin 5-HT 2a and dopamine D 3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

  本发明涉及式(I)化合物，其中R1、R2、X和n如规范中所定义，作为血清素5-HT2a和多巴胺D3受体的双重调节剂，其制造、包含它们的药物组合物以及它们用于治疗精神疾病、抑郁症和焦虑症、药物依赖、痴呆症和记忆障碍等其他疾病的用途。
• Dual modulators of 5HT2A and D3 receptors
  申请人：Hoffmann-La Roche Inc.

  公开号：US08829029B2

  公开（公告）日：2014-09-09

  The present invention relates to compounds of the formula (I) wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.

  本发明涉及公式(I)的化合物，其中R1、R2、X和n如规范中所定义，作为血清素5-HT2a和多巴胺D3受体的双重调节剂，它们的制造、含有它们的药物组合物以及它们用于治疗精神疾患以及其他疾病，如抑郁症和焦虑症、药物依赖、痴呆和记忆障碍的用途。
• DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2183245A2

  公开（公告）日：2010-05-12