virgineone | 1109270-86-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: virgineone
• CAS: 1109270-86-1
• 化学式: C₄₀H₆₃NO₁₂
• 分子量: 749.94
• InChiKey: WYTYMMOCYHJUDR-SJCLYCDYSA-N

反应信息

• 作为反应物：
  描述：

  virgineone 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以3 mg的产率得到21,22-dihydroxy-1-{4-hydroxy-5-[(4-hydroxyphenyl)methyl]-2-oxo-2,5-dihydro-1H-pyrrol-3-yl}-2-methyldocosane-1,11-dione
  参考文献：
  名称：

  Isolation, Structure Elucidation, and Biological Activity of Virgineone from Lachnum virgineum Using the Genome-Wide Candida albicans Fitness Test

  摘要：

  A glycosylated tetramic acid, virgineone (1), was isolated from saprotrophic Lachnum virgineum. The antifungal activity of the fermentation extract of L. virgineum was characterized in the Candida albicans fitness test as distinguishable from other natural products tested. Bioassay-guided fractionation yielded 1, a tyrosine-derived tetramic acid with a C-22 oxygenated chain and a beta-mannose. It displayed broad-spectrum antifungal activity against Candida spp. and Aspergillus fumigatus with a MIC of 4 and 16 mu g/mL, respectively. Virgineone was also identified in a number of Lachnum strains collected from diverse geographies and habitats.

  DOI：

  10.1021/np800511r