4-(3-Bromo-4-methoxyphenyl)butan-2-one | 646039-32-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3-Bromo-4-methoxyphenyl)butan-2-one
• CAS: 646039-32-9
• 化学式: C₁₁H₁₃BrO₂
• 分子量: 257.12
• InChiKey: FNTAMXRWDOFLIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION<br/>[FR] NOUVELLES DIHYDROQUINOLIZINONES POUR LE TRAITEMENT ET LA PROPHYLAXIE D'UNE INFECTION PAR LE VIRUS DE L'HÉPATITE B
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015113990A1

  公开（公告）日：2015-08-06

  The invention provides novel compounds having the general formula (I) wherein R1, R2 R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds in the treatment of the hepatitis B virus.

  这项发明提供了具有一般式（I）的新化合物，其中R1、R2、R3、R4、R5和R6如本文所述，包括这些化合物的组合物以及在治疗乙型肝炎病毒方面使用这些化合物的方法。
• SUBSTITUTED ISOXAZOLE DERIVATIVES AS ESTROGEN RECEPTOR MODULATORS
  申请人：CHIRON CORPORATION

  公开号：EP1102755A1

  公开（公告）日：2001-05-30
• NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
  申请人：F.Hoffmann-La Roche AG

  公开号：EP3099685A1

  公开（公告）日：2016-12-07
• US7482484B2
  申请人：——

  公开号：US7482484B2

  公开（公告）日：2009-01-27
• [EN] SUBSTITUTED ISOXAZOLE AS ESTROGEN RECEPTOR MODULATORS<br/>[FR] ISOXAZOLES SUBSTITUES COMME MODULATEURS DE RECEPTEUR D'OESTROGENES
  申请人：CHIRON CORP

  公开号：WO2000008001A1

  公开（公告）日：2000-02-17

  Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.