Arginine caprylate | 428818-38-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arginine caprylate
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;octanoic acid
• CAS: 428818-38-6
• 化学式: C14H30N4O4
• 分子量: 318.41
• InChiKey: PPXXXBJQFYWSJN-VWMHFEHESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.88
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  165
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMPOSITIONS COMPRISING POLYPEPTIDES AND RELATED METHODS OF DELIVERY
  申请人：Chiasma Inc.

  公开号：EP3210474A1

  公开（公告）日：2017-08-30

  The invention relates to a composition comprising a suspension which comprises an admixture of a hydrophobic medium and a solid form wherein the solid form comprises a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid, and wherein the medium chain fatty acid salt is present in the composition at an amount of 10% or more by weight, wherein the therapeutic agent is a polypeptide. The invention also relates to compositions for use in treating or preventing diseases by administration of the compositions to affected subjects.

  本发明涉及一种由悬浮液组成的组合物，悬浮液包括疏水介质和固体形式的混合物，其中固体形式包括治疗有效量的治疗剂和至少一种中链脂肪酸盐，中链脂肪酸盐在组合物中的含量为重量的 10%或更多，其中治疗剂为多肽。本发明还涉及用于治疗或预防疾病的组合物，方法是将组合物施用给受影响的受试者。
• Terlipressin compositions and their methods of use
  申请人：Chiasma, Inc.

  公开号：US10993984B2

  公开（公告）日：2021-05-04

  Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.

  公开了通过向受影响的受试者口服包含治疗有效量的特利加压素或其药学上可接受的盐的组合物来治疗或预防低血压（如神经源性正位性低血压或餐后低血压）或门静脉高压（如与门静脉高压相关的食管静脉曲张出血）或腹水（如与肝硬化相关的腹水）的方法。
• PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS OF DELIVERY
  申请人：Chiasma Inc.

  公开号：EP2343982A2

  公开（公告）日：2011-07-20
• TERLIPRESSIN COMPOSITIONS AND THEIR METHODS OF USE
  申请人：Chiasma Inc.

  公开号：EP3528828A1

  公开（公告）日：2019-08-28
• PHARMACEUTICAL COMPOSITIONS AND METHODS OF DELVERY
  申请人：Salama Paul

  公开号：US20110311621A1

  公开（公告）日：2011-12-22

  The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent (such as CCK-8, octreotide), at least one salt of a medium chain fatty acid, a matrix forming polymer and a hydrophobic(lipophilic) medium. A surfactant may be included in the suspension. The pharmaceutical compositions may be formulated in a capsule or tablet for oral delivery. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.