(R)-6-[[3-[[4-[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]piperidine-1-yl]carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | 1346654-37-2

• 分子结构分类: 有机化合物
• 英文名称: (R)-6-[[3-[[4-[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]piperidine-1-yl]carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
• 英文别名: 6-[3-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]piperidine-1-carbonyl]phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide
• CAS: 1346654-37-2
• 化学式: C₃₉H₄₁N₅O₈S
• 分子量: 739.849
• InChiKey: OTTAFDMNHGMXRG-DHUJRADRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  53
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  213
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• BI-FUNCTIONAL QUINOLINE ANALOGS
  申请人：Baker William R.

  公开号：US20110275622A1

  公开（公告）日：2011-11-10

  Provided are compounds of Formula I: wherein X is: R 1 and R 2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.

  提供的是以下化合物的结构式：其中X是：R1和R2，与它们结合的苯基一起可以形成一个螺环的、融合的杂环环，所有其他变量如本文所定义，以及它们在治疗肺部炎症或支气管痉挛中的应用，以及包含它们的组合物和制备这些化合物的方法。
• BIFUNCTIONAL QUINOLINE DERIVATIVES
  申请人：Gilead Sciences, Inc.

  公开号：EP2569285A1

  公开（公告）日：2013-03-20
• US8394829B2
  申请人：——

  公开号：US8394829B2

  公开（公告）日：2013-03-12
• [EN] BIFUNCTIONAL QUINOLINE DERIVATIVES<br/>[FR] DÉRIVÉS QUINOLINIQUES BIFONCTIONNELS
  申请人：GILEAD SCIENCES INC

  公开号：WO2011143105A1

  公开（公告）日：2011-11-17

  Provided are compounds of Formula (I): Wherein X is:(Formula (II)) or (Formula (III)) R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.