(-)-(2R,3R)-cis-3-acetoxy-8-chloro-5-<2-(dimethylamino)ethyl>2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one maleate | 130979-49-6

• 分子结构分类: 有机化合物
• 英文名称: (-)-(2R,3R)-cis-3-acetoxy-8-chloro-5-<2-(dimethylamino)ethyl>2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one maleate
• 英文别名: (+)-cis-2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-8-chloro-2, 3-dihydro-1,5-benzothiazepin-4(5H)-one maleate；(Z)-but-2-enedioic acid;[(2R,3R)-8-chloro-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
• CAS: 130979-49-6
• 化学式: C₄H₄O₄*C₂₂H₂₅ClN₂O₄S
• 分子量: 565.044
• InChiKey: FTUXVMVEKYLKGE-QYPUYXBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  159
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Agent having renal function-improving effect and diuretic effect and the use of a benzothiazepin derivative contained therein
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0278449A2

  公开（公告）日：1988-08-17

  Disclosed are an agent having a renal function-improving effect and a diuretic effect comprising as an active ingredient 2-(4-methoxyphenyl)-3-acetoxy-5-[2-­(dimethylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiaze­pin-4(5H)-one or a pharmaceutically acceptable acid addition salt thereof, and use of the same for preparing an agent having a renal function-improving effect and a diuretic effect.

  本发明公开了一种具有改善肾功能和利尿作用的制剂，其活性成分包括 2-(4-甲氧基苯基)-3-乙酰氧基-5-[2-(二甲基氨基)乙基]-8-氯-2,3-二氢-1,5-苯并硫氮杂卓-4(5H)-酮或其药学上可接受的酸加成盐，以及使用该活性成分制备具有改善肾功能和利尿作用的制剂的方法。
• Pharmaceutical composition for inhibiting platelet aggregation
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0476854A1

  公开（公告）日：1992-03-25

  There is disclosed a pharmaceutical composition for inhibiting the platelet aggregation comprising acetylsalicyclic acid or a pharmaceutically acceptable salt thereof and a 1,5-benzothiazepine derivative of the formula: wherein R¹ is a lower alkyl group or a lower alkoxy group, R² is hydrogen atom or a lower alkanoyl group, R³ is a lower alkyl group, R⁴ is hydrogen atom or a lower alkyl group and R⁵ is a lower alkyl group or a halogen atom, or a pharmaceutically acceptable salt thereof.

  本发明公开了一种抑制血小板聚集的药物组合物，该组合物由乙酰基水杨酸或其药学上可接受的盐和式 1,5-苯并硫氮杂卓衍生物组成： 其中，R¹为低级烷基或低级烷氧基，R²为氢原子或低级烷酰基，R³为低级烷基，R⁴为氢原子或低级烷基，R⁵为低级烷基或卤素原子，或其药学上可接受的盐。
• 8-chloro-benzothiazepine-compound for prophylaxis and treatment of sequelae of cerebral neurocyte necrosis
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0501442A1

  公开（公告）日：1992-09-02

  Disclosed is a prophylactic and curing agent for sequelae of cerebral neurocyte dyscrasia, which comprises a benzothiazepine compound represented by the formula:    (wherein R¹ to R⁴ each represent a lower alkyl group) or a phamacologically acceptable salt thereof as an active ingredient.

  本发明公开了一种脑神经细胞发育不良后遗症的预防和治疗剂，它包括一种由式表示的苯并硫氮杂卓化合物： (其中 R¹ 至 R⁴ 各代表一个低级烷基）或其药物学上可接受的盐作为活性成分。
• Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0127882B1

  公开（公告）日：1986-10-15
• Prophylactic and curing composition containing a 8-chlorobenzothiazepine compound and its use
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0250814B1

  公开（公告）日：1992-08-12