3-(3-hydroxyphenylethynyl)-7-(6-methyl-3-nitro-2-pyridyl)-1-oxa-2,7-diazaspiro[4.3]oct-2-ene | 1354930-94-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 3-(3-hydroxyphenylethynyl)-7-(6-methyl-3-nitro-2-pyridyl)-1-oxa-2,7-diazaspiro[4.3]oct-2-ene
• 英文别名: Phenol, 3-[2-[2-(6-methyl-3-nitro-2-pyridinyl)-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]ethynyl]-；3-[2-[2-(6-methyl-3-nitropyridin-2-yl)-5-oxa-2,6-diazaspiro[3.4]oct-6-en-7-yl]ethynyl]phenol
• CAS: 1354930-94-1
• 化学式: C₁₉H₁₆N₄O₄
• 分子量: 364.36
• InChiKey: LPXABVJQJMPLCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS
  申请人：Leonardi Amedeo

  公开号：US20120059015A1

  公开（公告）日：2012-03-08

  The invention is directed to methods of using antagonists selective for the metabotropic mGlu5 receptor to treat conditions of neuromuscular dysfunction of the lower urinary tract in a mammal. Provided are methods of treating a mammal suffering from a condition of neuromuscular dysfunction of the lower urinary tract by administering a selective mGlu5 antagonist. The selective mGlu5 antagonist may be administered alone or in combination with one or more additional therapeutic agents for treating such a condition. Also provided are methods of identifying selective mGlu5 antagonists that are useful for treating neuromuscular dysfunction of the lower urinary tract in a mammal. Methods for treating migraine and gastroesophageal reflux disease (GERD) using selective mGlu5 antagonists are also disclosed.

  本发明涉及使用选择性拮抗剂对代谢型mGlu5受体的方法，以治疗哺乳动物下尿道神经肌肉功能障碍的病症。提供了通过给予选择性mGlu5拮抗剂治疗患有下尿道神经肌肉功能障碍的哺乳动物的方法。该选择性mGlu5拮抗剂可以单独或与一种或多种其他治疗剂合并使用以治疗此类病症。还提供了用于治疗偏头痛和胃食管反流病（GERD）的选择性mGlu5拮抗剂的方法。同时还公开了用于鉴定对治疗哺乳动物下尿道神经肌肉功能障碍有用的选择性mGlu5拮抗剂的方法。
• US8580962B2
  申请人：——

  公开号：US8580962B2

  公开（公告）日：2013-11-12