| 155738-32-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• CAS: 155738-32-2
• 化学式: C₅₂H₃₆N₂O₂Pd
• 分子量: 827.29
• InChiKey: ZPXYEBXCJIUSCN-BRLFTNGRSA-N

反应信息

• 作为产物：
  描述：

  、 二苯基乙炔 以 氯苯 为溶剂， 以61%的产率得到
  参考文献：
  名称：

  Selective hetero- and carbo-cycle syntheses via masked cyclopalladated secondary amine and ketone functions

  摘要：

  The iodo-bridged or cationic cyclopalladated complexes Ib and Ic derived from N-phenyl-2-pyridylamine and 4b derived from phenyl-2-pyridylketone reacted with internal alkynes to yield five-membered heterocyclic 3 and carbocyclic products 6 with high chemoselectivity. The indoles 3b-3f, formed from Ib or Ic and disymmetric alkynes, were obtained regioselectively, suggesting that this reaction might be under both electronic and steric control. Analysis of the regiochemistry of this reaction has led us to propose a pathway involving a nucleophilic addition of the secondary amine function to an alkyne activated by eta(2)-coordination to palladium. The indenol derivatives 6, obtained as stable bis(O,N)-palladated chelates, result from the insertion of the alkyne into the Pd-C bond of 4b followed by attack of the palladated vinyl carbon atom on the electrophilic carbonyl function. In so far as their reactivities towards alkynes are concerned, Ib and Ic behave as masked cyclopalladated secondary amine functions and 4b as masked cyclopalladated ketone functions.

  DOI：

  10.1016/0022-328x(94)88054-9