Calcium;2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Calcium;2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
• 英文别名: calcium;2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
• 化学式: C12H14CaO14
• 分子量: 422.31
• InChiKey: OWFJMGQSOHDIPP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.55
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  270
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• [EN] METHOD FOR PREPARING CITRIC ACID<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ACIDE CITRIQUE
  申请人：COFCO LTD

  公开号：WO2011047634A1

  公开（公告）日：2011-04-28

  Provided is a method for preparing citric acid comprising the following steps: (1) contacting and reacting the fermentation liquid of citric acid with calcium carbonate and/or calcium hydroxide under the condition that the citric acid in the fermentation liquid can be converted into calcium hydrogen citrate, and subjecting the obtained slurry to a solid-liquid separation to obtain solid calcium hydrogen citrate and a first liquid phase; (2) subjecting the solid calcium hydrogen citrate obtained in step (1) to acidolysis to obtain citric acid; (3) contacting and reacting the first liquid phase obtained in step (1) with calcium carbonate and/or calcium hydroxide under the condition that the calcium hydrogen citrate dissolved in the first liquid phase can be converted into calcium citrate, subjecting the obtained slurry to a solid-liquid separation to obtain solid calcium citrate, and recycling the solid calcium citrate to step (1).

  提供一种制备柠檬酸的方法，包括以下步骤：(1) 将柠檬酸发酵液与碳酸钙和/或氢氧化钙接触并反应，在柠檬酸发酵液中的柠檬酸可以转化为氢氧化亚铁酸钙的条件下，将得到的浆料进行固液分离，得到固体氢氧化亚铁酸钙和第一液相；(2) 将步骤(1)中得到的固体氢氧化亚铁酸钙进行酸解，得到柠檬酸；(3) 将步骤(1)中得到的第一液相与碳酸钙和/或氢氧化钙接触并反应，在第一液相中溶解的氢氧化亚铁酸钙可以转化为柠檬酸钙的条件下，将得到的浆料进行固液分离，得到固体柠檬酸钙，并将固体柠檬酸钙回收至步骤(1)。
• Enhanced solubility of preformed calcium citrate by adding citric acid
  申请人：Pak Y.C. Charles

  公开号：US20070065542A1

  公开（公告）日：2007-03-22

  The present invention includes compositions and methods for the preparation and delivery of calcium citrate under physiological conditions by preparing solid preformed calcium citrate, adding citric acid to the calcium citrate, wherein citric acid is added to the calcium citrate in a molar ratio of between 0.1 and 0.6 mol of citric acid per mol of calcium citrate to provide a calcium citrate-citric acid mixture; and forming a tablet from the calcium citrate-citric acid mixture. The compositions and methods were found to increase the solubility of iron and calcium.

  本发明涉及制备和传递生理条件下的柠檬酸钙的组合物和方法，包括制备固体预形成柠檬酸钙，向柠檬酸钙中添加柠檬酸，其中柠檬酸以0.1至0.6摩尔比的摩尔比例加入到柠檬酸钙中，以提供柠檬酸钙-柠檬酸混合物；并从柠檬酸钙-柠檬酸混合物中制成片剂。该组合物和方法被发现可以增加铁和钙的溶解度。
• JPH0940604A
  申请人：——

  公开号：JPH0940604A

  公开（公告）日：1997-02-10
• [EN] ENHANCED SOLUBILITY OF PREFORMED CALCIUM CITRATE BY ADDING CITRIC ACID<br/>[FR] SOLUBILITE AMELIOREE DE CITRATE DE CALCIUM PREFORME PAR APPORT D'ACIDE CITRIQUE
  申请人：UNIV TEXAS

  公开号：WO2007035760A1

  公开（公告）日：2007-03-29

  [EN] The present invention includes compositions and methods for the preparation and delivery of calcium citrate under physiological conditions by preparing solid preformed calcium citrate, adding citric acid to the calcium citrate, wherein citric acid is added to the calcium citrate in a molar ratio of between 0.1 and 0.6 mol of citric acid per mol of calcium citrate to provide a calcium citrate-citric acid mixture; and forming a tablet from the calcium citrate-citric acid mixture. The compositions and methods were found to increase the solubility of iron and calcium.
  [FR] L'invention concerne des compositions et des méthodes servant à préparer et à administrer du citrate de calcium dans des conditions physiologiques, ce qui consiste à préparer du citrate de calcium solide préformé, à effectuer l'apport d'acide citrique au citrate de calcium selon un rapport molaire entre 0,1 et 0,6 mole d'acide citrique par mole de citrate de calcium afin d'obtenir un mélange citrate de calcium-acide citrique, puis à créer un comprimé à partir de ce mélange. On a découvert que ces compositions et ces méthodes augmentent la solubilité du fer et du calcium.