N-{2-[ethyl(m-tolyl)amino]ethyl}-N'-[(7R)-7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl]urea | 745784-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-{2-[ethyl(m-tolyl)amino]ethyl}-N'-[(7R)-7-hydroxy-5,6,7,8-tetrahydro-1-naphthalenyl]urea
• 英文别名: 1-[2-(N-ethyl-3-methylanilino)ethyl]-3-[(7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]urea
• CAS: 745784-24-1
• 化学式: C₂₂H₂₉N₃O₂
• 分子量: 367.491
• InChiKey: ARBACKXLZXMAFG-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  64.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES<br/>[FR] DERIVES D'HYDROXY-TETRAHYDRO-NAPHTALENYLUREE
  申请人：BAYER HEALTHCARE AG

  公开号：WO2004072020A1

  公开（公告）日：2004-08-26

  This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity as VRl antagonist and are useful for the prophylaxis and treatment of diseases associated with VRl activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.

  这项发明涉及羟基-四氢-萘尿素衍生物及其盐，可作为药物配方的有效成分。本发明的羟基-四氢-萘尿素衍生物具有优异的VRl拮抗活性，适用于预防和治疗与VRl活性相关的疾病，特别是用于治疗尿失禁、急迫性尿失禁、过度活跃膀胱、慢性疼痛、神经痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、炎症性疾病、哮喘和COPD的治疗。
• Hydroxy-tetrahydro-naphthalenylurea derivatives
  申请人：Yura Takeshi

  公开号：US20070027187A1

  公开（公告）日：2007-02-01

  This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excellent activity as VR1 antagonist and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.

  本发明涉及羟基四氢萘基脲衍生物及其盐，它们是制备药物的有效成分。本发明的羟基四氢萘基脲衍生物具有优异的VR1拮抗剂活性，可用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁、急迫性尿失禁、过度活动膀胱、慢性疼痛、神经病性疼痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、炎症性疾病、哮喘和COPD。
• HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
  申请人：Bayer HealthCare AG

  公开号：EP1594836A1

  公开（公告）日：2005-11-16
• US7423175B2
  申请人：——

  公开号：US7423175B2

  公开（公告）日：2008-09-09