4,4'-(1,4-phenylene)dibutyl diiodie | 853261-37-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-(1,4-phenylene)dibutyl diiodie
• 英文别名: 1,4-bis(4-iodobutyl)benzene
• CAS: 853261-37-7
• 化学式: C₁₄H₂₀I₂
• 分子量: 442.122
• InChiKey: GDYYYZOSUHKDFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4,4'-(1,4-phenylene)dibutyl diiodie 在 盐酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 6,6'-(1,4-phenylene)bis[2-(methylthio)hexanal]
  参考文献：
  名称：

  Highly Regioselective Transformation of out/out-equatorial Bis(formylmethano)[60]fullerenes:  Construction of Dissymmetric [60]Fullerene-Centered Triads

  摘要：

  [GRAPHICS]Three kinds of out/out-equatorial bis( formylmethano)[ 60] fullerenes ( 1b-d) were obtained by the tether-directed bifunctionalization of [ 60] fullerene with bis( alpha-formylsulfonium ylide) s. The condensation of aromatic amines with 1b-d proceeded with an unexpectedly high regioselectivity to give one of two possible regioisomers of mono-imines as the main products ( the ratio of the regioisomers, up to 97: 3). By the transformation of the remaining formyl group in the mono-imines thus obtained, the corresponding dissymmetric bis-imines were efficiently synthesized.

  DOI：

  10.1021/jo060110+
• 作为产物：
  描述：

  1,4-Benzenedibutanol, dimethanesulfonate 在 sodium iodide 作用下， 以 丙酮 为溶剂， 以87%的产率得到4,4'-(1,4-phenylene)dibutyl diiodie
  参考文献：
  名称：

  Highly Regioselective Transformation of out/out-equatorial Bis(formylmethano)[60]fullerenes:  Construction of Dissymmetric [60]Fullerene-Centered Triads

  摘要：

  [GRAPHICS]Three kinds of out/out-equatorial bis( formylmethano)[ 60] fullerenes ( 1b-d) were obtained by the tether-directed bifunctionalization of [ 60] fullerene with bis( alpha-formylsulfonium ylide) s. The condensation of aromatic amines with 1b-d proceeded with an unexpectedly high regioselectivity to give one of two possible regioisomers of mono-imines as the main products ( the ratio of the regioisomers, up to 97: 3). By the transformation of the remaining formyl group in the mono-imines thus obtained, the corresponding dissymmetric bis-imines were efficiently synthesized.

  DOI：

  10.1021/jo060110+

文献信息

• Mono- and Bis-Thiazolium Salts Have Potent Antimalarial Activity
  作者：Abdallah Hamzé、Eric Rubi、Pascal Arnal、Michel Boisbrun、Carole Carcel、Xavier Salom-Roig、Marjorie Maynadier、Sharon Wein、Henri Vial、Michèle Calas

  DOI：10.1021/jm0492608

  日期：2005.5.1

  Three new series comprising 24 novel cationic choline analogues and consisting of mono- or his (N or C-5-duplicated) thiazolium salts have been synthesized. Bis-thiazolium salts showed potent antimalarial activity (much superior to monothiazoliums). Among them, bis-thiazolium salts 12 and 13 exhibited IC50 values of 2.25 nM and 0.65 nM, respectively, against P. falciparum in vitro. These compounds also demonstrated good in vivo activity (ED50 <= 0.22 mg/kg), and low toxicity in mice infected by Plasmodium vinckei.