Arginine dihydrate | 17585-56-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arginine dihydrate
• 英文别名: (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;dihydrate
• CAS: 17585-56-7
• 化学式: C6H18N4O4
• 分子量: 210.23
• InChiKey: IQTBLJUKEVUNRU-FHNDMYTFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  130
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Crystalline dihydrate of a cephalosporin dihydrochloride salt and injectable compositions thereof
  申请人：Bristol-Myers Squibb Company

  公开号：EP0587121A1

  公开（公告）日：1994-03-16

  The present invention relates to a new crystalline dihydrochloride dihydrate salt of the cephalosporin antibiotic, cefepime. In particular, this invention provides a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having enhanced stability and a specific x-ray powder diffraction pattern as described herein. The present invention also provides physical admixtures of the new crystalline dihydrochloride dihydrate salt of cefepime with a pharmaceutically acceptable non-toxic organic or inorganic base. In particular, this invention provides physical admixtures of a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having a specific X-ray powder diffraction pattern as described herein with L(+) arginine.

  本发明涉及头孢菌素类抗生素头孢吡肟的一种新的结晶二盐酸盐二水合物。特别是，本发明提供了一种温度和湿度稳定的头孢吡肟二盐酸盐二水合物结晶形式，具有更高的稳定性和本文所述的特定 X 射线粉末衍射图样。本发明还提供了头孢吡肟的新型结晶二盐酸盐二水合物与药学上可接受的无毒有机或无机碱的物理混合物。特别是，本发明提供了具有本文所述特定 X 射线粉末衍射图样的头孢吡肟二盐酸盐二水合物晶体的温度和湿度稳定型与 L（+）精氨酸的物理混合物。
• A method for the production of a basic amino acid
  申请人：Ajinomoto Co., Inc.

  公开号：EP0714884A1

  公开（公告）日：1996-06-05

  This method results in a purified basic amino acid which does not cause problems in filterability even when a neutral or acidic aqueous solution containing the basic amino acid is processed by filtration. A method for the purification of a basic amino acid wherein an alkaline aqueous solution of the amino acid produced by a fermentation method is filtered through a tight-ultrafiltaration membrane.

  这种方法可提纯碱性氨基酸，即使用过滤法处理含有碱性氨基酸的中性或酸性水溶液，也不会产生过滤性问题。 一种提纯碱性氨基酸的方法，其中通过发酵法生产的碱性氨基酸水溶液通过紧致超滤膜进行过滤。
• DERIVES OLIGOPEPTIDIQUES DU COLLAGENE ET LEUR UTILISATION POUR LA PREVENTION DE LA CATARACTE SECONDAIRE
  申请人：LABORATOIRE CHAUVIN SA

  公开号：EP0651763A1

  公开（公告）日：1995-05-10
• 2-METHYLSULPHANYL-6-NITRO-7-OXO-1, 2, 4-TRIAZOLO [5, 1-C][1, 2, 4]TRIAZINIDE L-ARGININE DIHYDRATE ACTIVE TOWARD WEST NILE VIRUS
  申请人：Limited Liability Company "Ural Center of Biopharmaceutical Technology"

  公开号：EP3064501B1

  公开（公告）日：2019-08-21
• JPS5735548A
  申请人：——

  公开号：JPS5735548A

  公开（公告）日：1982-02-26