Novel Microfluidic System and Method for Capturing Cells
申请人:Tran Phuong-Lan
公开号:US20080318203A1
公开(公告)日:2008-12-25
The invention concerns a microfluidic device and its uses for capturing subset of cells in a biological fluid. Said device comprises a chamber (
1
) for circulating fluids whereof an inner wall (
5
) is provided with a covalent immobilization surface in the form of an organized self-assembled silane layer, whereto is fixed a layer of biomolecules for specific identification of the population of cells.
COMPOUND HAVING AFFINITY SUBSTANCE TO SOLUBLE PROTEIN, CLEAVABLE PORTION AND REACTIVE GROUP, OR SALT THEREOF
申请人:Ajinomoto Co., Inc.
公开号:US20200190165A1
公开(公告)日:2020-06-18
The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):
A-L-B-R (I)
wherein
A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.