homoglutathione | 128960-75-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: homoglutathione
• 英文别名: 2-Amino-5-[[1-(1-carboxyethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
• CAS: 128960-75-8
• 化学式: C₁₁H₁₉N₃O₆S
• 分子量: 321.354
• InChiKey: UTYLFDUOWWLTBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  160
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  四氯金酸水合物 、 homoglutathione 在 sodium tetrahydroborate 作用下， 以 甲醇 、 水 为溶剂， 生成 Au22(homodlutathione)17 、 Au18(homodlutathione)14 、 Au15(homodlutathione)13 、 Au22(homodlutathione)16 、 Au10(homodlutathione)10
  参考文献：
  名称：

  重新审视受谷胱甘肽保护的金簇：弥合金 (I)-硫醇盐配合物和硫醇盐保护的金纳米晶体之间的差距

  摘要：

  由三肽谷胱甘肽 (GSH) 分子保护的小金簇（约 1 nm）是通过 Au(I)-SG 聚合物在低温下的还原分解制备的，并通过聚丙烯酰胺凝胶电泳 (PAGE ）。之前通过电喷雾电离 (ESI) 质谱法 (Negishi, Y. et al. J.Am. Chem. Soc. 2004, 126, 6518) 确定的分馏簇的化学成分通过利用新鲜制备的样品进行重新评估，更高质量分辨率，以及更准确的质量校准；九个最小的组分被重新分配为 Au10(SG)10、Au15(SG)13、Au18(SG)14、Au22(SG)16、Au22(SG)17、Au25(SG)18、Au29(SG)20、Au33 (SG)22 和 Au39(SG)24。通过测量分离的 Au:S(hG) 簇的质谱进一步证实了这些分配，其中 h-GSH 是一种高谷胱甘肽。提出一系列孤立的 Au:SG 簇对应于不断增长的 Au 核的动力

  DOI：

  10.1021/ja042218h

文献信息

• SUPRAMACROMOLECULAR POLYMER COMPLEXES PROVIDING CONTROLLED NITRIC OXIDE RELEASE FOR HEALING WOUNDS
  申请人：Lee Ping I.

  公开号：US20100303891A1

  公开（公告）日：2010-12-02

  A bio-adhesive supramacromolecular complex of the general formula: wherein R 1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R 2 is independently selected from the group consisting of C1-6 alkyl; R 3 and R 4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R 5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T 1 , T 2 , T 3 and T 4 are independently selected polymer residues; and m 1 , m 2 , m 3 , n 1 and n 2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×10 3 to 1×10 7 and Q has a molecular weight of about 1×10 3 to 1×10 7 . The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described.

  一种生物黏合剂超分子复合物的一般式：其中，R1是从未取代或取代有烷氧基的烷烃群中独立选择的；R2是从C1-6烷基群中独立选择的；R3和R4是从可选取代的脂肪族或芳香族烷基群中独立选择的；R5是从H或C1-6烷基群中独立选择的；W是含有氢键受体官能团的实体；Y是羧酸酯或酰胺键；R是独立选择的肽连接基；T1、T2、T3和T4是独立选择的聚合物残基；m1、m2、m3、n1和n2是至少选择25的整数；其中P的分子量约为1×103至1×107，Q的分子量约为1×103至1×107。该复合物提供了比现有化合物更长时间的控制性一氧化氮释放，适用于局部递送系统。本文描述了新的组合物、制备方法、包括层层组装涂层、电纺和超声雾化的装置、含有复合物的皮肤覆盖物以及医学用途。
• CRYSTAL OF REDUCED-FORM GLUTATHIONE AND METHOD FOR PRODUCING SAME
  申请人：Kyowa Hakko Bio Co., Ltd.

  公开号：EP3431488A1

  公开（公告）日：2019-01-23

  According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.

  根据本发明，提供了一种杂质含量降低，特别是 L-半胱氨酰-L-甘氨酸含量降低的还原型谷胱甘肽晶体及其生产方法。本发明涉及一种还原型谷胱甘肽晶体，其中在高效液相色谱（HPLC）分析中，L-半胱氨酰-L-甘氨酸的峰面积相对于还原型谷胱甘肽的峰面积为 0.02 或更小，还原型谷胱甘肽的峰面积取 100。
• Crystal of reduced glutathione and method for producing same
  申请人：KYOWA HAKKO BIO CO., LTD.

  公开号：US10858393B2

  公开（公告）日：2020-12-08

  According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.

  根据本发明，提供了一种杂质含量降低，特别是 L-半胱氨酰-L-甘氨酸含量降低的还原型谷胱甘肽晶体及其生产方法。本发明涉及一种还原型谷胱甘肽晶体，其中在高效液相色谱（HPLC）分析中，L-半胱氨酰-L-甘氨酸的峰面积相对于还原型谷胱甘肽的峰面积为 0.02 或更小，还原型谷胱甘肽的峰面积取 100。
• CRYSTAL OF REDUCED GLUTATHIONE AND METHOD FOR PRODUCING SAME
  申请人：KYOWA HAKKO BIO CO., LTD.

  公开号：US20190071466A1

  公开（公告）日：2019-03-07

  According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method for producing the same are provided. The present invention relates to a crystal of reduced glutathione, wherein, in a high-performance liquid chromatography (HPLC) analysis, the peak area of L-cysteinyl-L-glycine is 0.02 or less with respect to the peak area of reduced glutathione which is taken as 100.
• US8992945B2
  申请人：——

  公开号：US8992945B2

  公开（公告）日：2015-03-31