(2R,3R)-2-N-benzyloxycarbonylamino-3-O-tert-butyldimethylsilyl-4-O-(triisopropylsilyl)butane-1,3,4-triol | 956506-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R)-2-N-benzyloxycarbonylamino-3-O-tert-butyldimethylsilyl-4-O-(triisopropylsilyl)butane-1,3,4-triol
• CAS: 956506-45-9
• 化学式: C₂₇H₅₁NO₅Si₂
• 分子量: 525.877
• InChiKey: BLNRMMWIMIYJII-RPBOFIJWSA-N

反应信息

• 作为反应物：
  描述：

  (2R,3R)-2-N-benzyloxycarbonylamino-3-O-tert-butyldimethylsilyl-4-O-(triisopropylsilyl)butane-1,3,4-triol 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以42%的产率得到(2R,3R)-1-O-tert-butyldimethylsilyl-2-N-benzyloxycarbonylamino-4-O-(triisopropylsilyl)butane-1,3,4-triol
  参考文献：
  名称：

  Synthetic route towards (5R,2′S,5′S,6′S)-ribosyl-diazepanone, an analogue core of the liposidomycins

  摘要：

  The synthesis of (5R,2'S,5'S,6'S)-ribosyl-diazepanone, an analogue core of liposidomycins is described. The core ribosyl seven-membered heterocycle of nucleoside antibiotic liposidomycins was formed by reductive amination of an alpha-ribosylamino ester derived from D-ribose, and an amino aldehyde derived from methyl 4-triisopropylsilyloxy-3-oxobutanoate, followed by a peptidic coupling reaction. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.07.023
• 作为产物：
  描述：

  methyl (2S,3R)-2-N-benzyloxycarbonylamino-4-triisopropylsilyloxy-3-(tert-butyldimethylsilyloxy)butanoate 在 sodium tetrahydroborate 、 calcium chloride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 以91%的产率得到(2R,3R)-2-N-benzyloxycarbonylamino-3-O-tert-butyldimethylsilyl-4-O-(triisopropylsilyl)butane-1,3,4-triol
  参考文献：
  名称：

  Synthetic route towards (5R,2′S,5′S,6′S)-ribosyl-diazepanone, an analogue core of the liposidomycins

  摘要：

  The synthesis of (5R,2'S,5'S,6'S)-ribosyl-diazepanone, an analogue core of liposidomycins is described. The core ribosyl seven-membered heterocycle of nucleoside antibiotic liposidomycins was formed by reductive amination of an alpha-ribosylamino ester derived from D-ribose, and an amino aldehyde derived from methyl 4-triisopropylsilyloxy-3-oxobutanoate, followed by a peptidic coupling reaction. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.07.023