(E)-5-(2-(1-oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)vinyl)benzene-1,3-diol | 1352457-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-5-(2-(1-oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)vinyl)benzene-1,3-diol
• 英文别名: HO-4415
• CAS: 1352457-93-2
• 化学式: C₁₇H₂₂NO₃
• 分子量: 288.367
• InChiKey: JFFXLNWGGNZRLN-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  44.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-5-(2-(1-oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)vinyl)benzene-1,3-diol 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以22%的产率得到(E)-5-(2-(1-hydroxy-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)vinyl)benzene-1,3-diol hydrochloride
  参考文献：
  名称：

  Synthesis and study of new paramagnetic resveratrol analogues

  摘要：

  New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNF alpha production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.066
• 作为产物：
  描述：

  1-oxyl-4-vinyl-2,2,6,6-tetramethyl-1,2,5,6-tetrahydropyridine 、 3,5-diacetoxyiodobenzene 在 四丁基溴化铵 、 potassium acetate 、 palladium diacetate 、 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 反应 4.0h， 以55%的产率得到(E)-5-(2-(1-oxyl-2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridin-4-yl)vinyl)benzene-1,3-diol
  参考文献：
  名称：

  Synthesis and study of new paramagnetic resveratrol analogues

  摘要：

  New resveratrol analogues containing five- and six-membered nitroxides and isoindoline nitroxides were synthesized. These new compounds were compared to resveratrol based on their ABTS radical scavenging ability as well on their capacity to suppress inflammatory process in macrophages induced by lipopolysaccharides. The ABTS and ROS scavenging activities of new molecules were the same or weaker than that of resveratrol, but some of paramagnetic resveratrol derivatives suppressed nitrite and TNF alpha production more efficiently than resveratrol. Based on these results the new nitroxide and phenol containing hybrid molecules can be considered as new antioxidant and anti-inflammatory agents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.066