1-[(3aS,4R,6R)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(3aS,4R,6R)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4-dione
• 化学式: C₁₂H₁₆N₂O₆
• 分子量: 284.26
• InChiKey: GFDUSNQQMOENLR-HZRXXTQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION
  申请人：Manoharan Muthiah

  公开号：US20120035115A1

  公开（公告）日：2012-02-09

  The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

  该发明涉及公式I或II的化合物：在一种实施方式中，该发明涉及化合物和用于将配体与寡核苷酸结合的过程。该发明进一步涉及治疗各种疾病和疾病的方法，例如病毒感染、细菌感染、寄生虫感染、癌症、过敏、自身免疫疾病、免疫缺陷和免疫抑制。
• D-AMINO ACID COMPOUNDS FOR LIVER DISEASE
  申请人：Idenix Pharmaceuticals LLC

  公开号：US20160002281A1

  公开（公告）日：2016-01-07

  Provided herein are compounds, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病和病状（包括HCV感染）的化合物、组合物和方法。在某些实施例中，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• [EN] D-AMINO ACID COMPOUNDS FOR LIVER DISEASE<br/>[FR] COMPOSÉS D'ACIDE D-AMINÉ CONTRE LES MALADIES HÉPATIQUES
  申请人：IDENIX PHARMACEUTICALS INC

  公开号：WO2013177219A1

  公开（公告）日：2013-11-28

  Provided herein are compounds comprising a D-amino acid, compositions and methods for the treatment of liver disease and conditions, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了包含D-氨基酸的化合物、用于治疗肝脏疾病和状况（包括HCV感染）的组合物和方法。在某些实施例中，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒剂联合使用。
• REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS
  申请人：IONOVATION GMBH

  公开号：US20150240295A1

  公开（公告）日：2015-08-27

  The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with, essentially, complementary sequences (in the following referred to as sample oligo-nucleotides, sample sequences or sample nucleic acids), which belong to a library of sequences. Further, the invention relates to nucleolipids used in the method of the invention and a process for the preparation of said nucleolipids. In addition, the invention refers to a pharmaceutical composition comprising said nucleolipids.

  本发明涉及一种用于分离和/或识别已知或未知的核酸序列（目标序列）的方法，该方法可以通过与基本互补序列（以下称为样品寡核苷酸、样品序列或样品核酸）进行碱基特异性杂交来标记选定的序列（目标序列），这些序列属于序列库。此外，本发明涉及用于本发明方法的核脂质和制备该核脂质的过程。此外，本发明还涉及包含所述核脂质的制药组合物。
• [EN] 6-AZA-NUCLEOSIDE PRODRUGS AS ANTIVIRAL AGENTS FOR TREATING VIRUS INFECTIONS<br/>[FR] PROMÉDICAMENTS DE 6-AZA-NUCLÉOSIDE COMME AGENTS ANTIVIRAUX POUR LE TRAITEMENT D'INFECTIONS VIRALES
  申请人：SOUTHERN RES INST

  公开号：WO2022133323A1

  公开（公告）日：2022-06-23

  The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-home encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制病毒感染的6-aza-核苷类前药物，以及治疗病毒感染的方法，例如人类免疫缺陷病毒（HIV）、人乳头瘤病毒（HPV）、水痘、传染性单核细胞增多症、腮腺炎、麻疹、风疹、带状疱疹、埃博拉、病毒性胃肠炎、病毒性肝炎、病毒性脑膜炎、人类副流感病毒1型、副流感病毒2型、副流感病毒3型、呼吸道合胞病毒、病毒性肺炎、黄热病病毒、蜱媒乙型脑炎病毒、基孔肯雅病毒（CHIKV）、委内瑞拉马蹄病毒脑炎病毒（VEEV）、东部马脑炎病毒（EEEV）、西部马脑炎病毒（WEEV）、登革热病毒（DENV）、流感、西尼罗河病毒（WNV）、寨卡病毒（ZIKV）、中东呼吸综合症（MERS）、严重急性呼吸综合症（SARS）以及2019冠状病毒病（COVID-19）。本摘要旨在作为特定领域搜索的工具，不限制本发明。