7-(2,4-dimethoxybenzyl)-3-methyl-3,7-dihydropurine-2,6-dione | 1000401-09-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-(2,4-dimethoxybenzyl)-3-methyl-3,7-dihydropurine-2,6-dione
• CAS: 1000401-09-1
• 化学式: C₁₅H₁₆N₄O₄
• 分子量: 316.316
• InChiKey: BLXZPKVWQUTLNO-UHFFFAOYSA-N

物化性质

• 熔点：
  182 °C(Solvent: Methanol)
• 密度：
  1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

反应信息

• 作为反应物：
  描述：

  7-(2,4-dimethoxybenzyl)-3-methyl-3,7-dihydropurine-2,6-dione 、 碘甲烷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以86%的产率得到7-(2,4-dimethoxybenzyl)-1,3-dimethyl-3,7-dihydropurine-2,6-dione
  参考文献：
  名称：

  Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

  摘要：

  An efficient synthesis of selectively N-substituted xanthine derivatives is described. Cyclocondensation of a suitably protected ammoimidazole with methyl-2-phenylthioethyl carbamate, followed by oxidation of sulfur to the sulfone, provides access to an orthogonally 1,7-protected xanthine, which may then be regioselectively alkylated and deprotected under mild conditions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.09.067
• 作为产物：
  描述：

  1-(2-phenylsulfonylethyl)-7-(2,4-dimethoxybenzyl)-3-methyl-3,7-dihydropurine-2,6-dione 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到7-(2,4-dimethoxybenzyl)-3-methyl-3,7-dihydropurine-2,6-dione
  参考文献：
  名称：

  Efficient synthesis of 1,3,7-substituted xanthines by a safety-catch protection strategy

  摘要：

  An efficient synthesis of selectively N-substituted xanthine derivatives is described. Cyclocondensation of a suitably protected ammoimidazole with methyl-2-phenylthioethyl carbamate, followed by oxidation of sulfur to the sulfone, provides access to an orthogonally 1,7-protected xanthine, which may then be regioselectively alkylated and deprotected under mild conditions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.09.067