8-Methylidene-1,3-diazaspiro[4.5]decane-2,4-dione | 906456-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 8-Methylidene-1,3-diazaspiro[4.5]decane-2,4-dione
• CAS: 906456-06-2
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: DPBWZELCMVVRNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Methylidene-1,3-diazaspiro[4.5]decane-2,4-dione 在 diisopinocampheylborane 、 乙醛 作用下， 以 四氢呋喃 为溶剂， 反应 28.0h， 以86%的产率得到(2,4-Dioxo-1,3-diazaspiro[4.5]decan-8-yl)methylboronic acid
  参考文献：
  名称：

  Hydroboration of Alkene-Containing Hydantoins

  摘要：

  A direct hydroboration of alkene-containing hydantoins using diisopinocampheylborane has been developed that can be used to prepare boronated amino acids. The method is successful because boronic acids are stable to the conditions employed for hydrolyzing hydantoins.

  DOI：

  10.1021/op060052u

文献信息

• HYDRAZINO-SUBSTITUTED HETEROCYCLIC NITRILE COMPOUNDS AND USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1739081A1

  公开（公告）日：2007-01-03

  A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an nitrogen atom(s), a oxygen atom(s) and a sulfur atom(s) which may be oxidized, in addition to said nitrogen atom in the ring; J is a bond or a spacer having from 1 to 8 atoms; R, R1, R2 and R3 is each independently hydrogen atom or a substituent; n is 0 or an integer of 1 to 10), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof; and an agent for prevention and/or treatment for a cysteine protease-related disease, such as osteoporosis, comprising it as an active ingredient are provided.

  一种对半胱氨酸蛋白酶具有抑制活性的化合物，由式 (I) 表示： (其中环 X 是杂环基团，除了环中的所述氮原子外，还可包含 1 至 4 个选自氮原子、氧原子和可被氧化的硫原子的杂原子；J 是具有 1 至 8 个原子的键或间隔物；R、R1、R2 和 R3 各自独立地是氢原子或取代基；n为0或1至10的整数）、其盐、其溶液或其N-氧化物或其原药；以及包含其作为活性成分的用于预防和/或治疗半胱氨酸蛋白酶相关疾病（如骨质疏松症）的制剂。
• Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof
  申请人：Ohmoto Kazuyuki

  公开号：US20070232586A1

  公开（公告）日：2007-10-04

  A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an nitrogen atom(s), a oxygen atom(s) and a sulfur atom(s) which may be oxidized, in addition to said nitrogen atom in the ring; J is a bond or a spacer having from 1 to 8 atoms; R, R 1 , R 2 and R 3 is each independently hydrogen atom or a substituent; n is 0 or an integer of 1 to 10), a salt thereof, a solvate thereof, or an N-oxide thereof, or a prodrug thereof; and an agent for prevention and/or treatment for a cysteine protease-related disease, such as osteoporosis, comprising it as an active ingredient are provided.
• [EN] HETEROCYCLES AS NICOTINIC ACID RECEPTOR AGONISTS FOR THE TREATMENT OF DYYSLIPIDEMIA<br/>[FR] HETEROCYCLES EN TANT QU'AGONISTES DU RECEPTEUR DE L'ACIDE NICOTINIQUE DESTINES AU TRAITEMENT DES DYSLIPIDEMIES
  申请人：SCHERING CORPOORATION

  公开号：WO2007087204A2

  公开（公告）日：2007-08-02

  [EN] A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.
  [FR] L'invention concerne un composé présentant une structure générale répondant à la formule (I) : ou un tautomère, un ester, un solvate ou un sel pharmaceutiquement acceptable celui-ci, utiles dans le traitement de pathologies, troubles ou états tels que le syndrome métabolique ou une dyslipidémie.