4,4'-异亚丙基二[O-氯苯酚] | 79-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4'-异亚丙基二[O-氯苯酚]
• 中文别名: 3,3'-二氯双酚A；1,6-二甲氧基己烷
• 英文名称: 2,2-bis(3-chloro-4-hydroxyphenyl)propane
• 英文别名: 2,2-bis(3'-chloro-4'-hydroxyphenyl)-propane；3,3'-Dichlorobisphenol A；2,2′-dichloro-4,4′-isopropylidenediphenol A；3,3'-dichloro-4,4'-dihydroxydiphenylpropane；3,3'-Dichloro-4,4'-isopropylidenediphenol；4,4'-isopropylidenebis(2-chlorophenol)；2-chloro-4-[2-(3-chloro-4-hydroxyphenyl)propan-2-yl]phenol
• CAS: 79-98-1
• 化学式: C₁₅H₁₄Cl₂O₂
• 分子量: 297.181
• InChiKey: XBQRPFBBTWXIFI-UHFFFAOYSA-N

物化性质

• 熔点：
  82-85 °C
• 沸点：
  399.9±37.0 °C(Predicted)
• 密度：
  1.329±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于乙腈（少许）、DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4'-异亚丙基二[O-氯苯酚] 在 吡啶 、 硫酸 、 乙酸酐 、 ammonium hydroxide 作用下， 反应 0.75h， 生成 C₁₅H₁₄Cl₂O₈S₂*2H₃N
  参考文献：
  名称：

  Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates

  摘要：

  In order to obtain strong inhibitors of classical pathway of complement activation the low weight negative charged compounds have been investigated. On the basis of bisphenol A anionic derivatives with one or two carboxylic, sulphate and phosphate groups the critical role of negative charged groups for complement-inhibiting activity has been established. It was determined that two sulphate or phosphate groups in the molecule provide the most inhibiting effect. At the next stage a set of bisphenol disulphates of varying structures has been synthesized and investigated. Bulky hydrophobic groups (cyclohexyliden, fluorenyliden, anthronyliden) at the central part of the bisphenol molecule it was found to increase complement-inhibiting activity markedly. The replacement of the ortho-positions to the charged group by halogens or alkyl groups (allyl, propyl) increases the inhibiting effect. It was showed by ELISA that several compounds studied interact with Clq, Cl (r) over bar /Cl (s) over bar components of complement. For the set of bisphenol disulphates the QSAR equation with hydrophobic coefficient and electronic parameters has been formulated. Both hydrophobic and electrostatic interactions it was established to have a great significance for the inhibition of classical pathway of complement activation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.11.056
• 作为产物：
  描述：

  双酚A 在 磺酰氯 作用下， 以95%的产率得到4,4'-异亚丙基二[O-氯苯酚]
  参考文献：
  名称：

  Selective monochlorination of ketones and aromatic alcohols

  摘要：

  在液相中，将亚磺酰氯与一个有机反应物反应，该有机反应物是一个酮或芳香族醇，其在两个邻位碳上未被取代，同时存在一种调节剂，所述调节剂被选择自1-3碳的脂肪醇和2-6碳的脂肪醚组成的群体中，足够的调节剂存在以选择性地产生一个基本上不含有每个羰基或芳香族羟基多于一个氯原子的化合物的产物。所得的产物，如单氯代丙酮、单氯代环己酮、单氯代苯酚和2,2-双(3-氯-4-羟基苯基)丙烷，可用作化学中间体和阻燃聚合物的单体。

  公开号：

  US04310702A1

文献信息

• Method for the preparation of aromatic chloroformates
  申请人：Davis Charles Gary

  公开号：US20060293535A1

  公开（公告）日：2006-12-28

  A method for preparing an aromatic chloroformate comprising, introducing a mixture of at least one aromatic hydroxyl compound, phosgene, at least one solvent, and at least one organic base into a flow reactor to obtain a unidirectionally flowing reaction mixture. The unidirectionally flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aromatic chloroformate.

  一种制备芳香氯甲酸酯的方法包括，将至少一种芳香羟基化合物、光气、至少一种溶剂和至少一种有机碱的混合物引入流动反应器中，以获得单向流动的反应混合物。将单向流动的反应混合物保持在约0°C至约60°C的温度下，以产生包含芳香氯甲酸酯的单一产物流。
• Method for the preparation of aliphatic chloroformates
  申请人：Davis Charles Gary

  公开号：US20060084822A1

  公开（公告）日：2006-04-20

  A method for preparing an aliphatic chloroformate comprising, introducing a mixture of at least one aliphatic hydroxyl compound, phosgene, at least one solvent, and optionally at least one organic base into a flow reactor to obtain a unidirectional flowing reaction mixture. The at least one aliphatic hydroxyl compound comprises at least one aliphatic hydroxyl group. The unidirectional flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aliphatic chloroformate.

  制备脂肪基氯甲酸酯的方法包括，将至少一种脂肪基羟基化合物、光气、至少一种溶剂以及可选的至少一种有机碱的混合物引入流动反应器中，以获得单向流动的反应混合物。至少一种脂肪基羟基化合物包括至少一种脂肪基羟基。将单向流动的反应混合物保持在约0°C至约60°C的温度下，以产生包含脂肪基氯甲酸酯的单一产物流。
• Organic Silicon-Based Compound And Method Of Producing The Same
  申请人：Kikuchi Taketoshi

  公开号：US20070203275A1

  公开（公告）日：2007-08-30

  Provided are an organic silicon compound of the following formula (I): (wherein, R 1 to R 20 represent each independently alkyl, alkoxy, aryloxy, cycloalkyl, alkylcycloalkyl, aryl, dialkylamino or the like, and the aryloxy and aryl may be substituted with a substituent selected from the group consisting of alkyl, alkoxy and alkoxyalkyl.) which can be used for suppression of coloration and thermal deterioration of an organic material in molding, and an organic material composition containing the organic silicon compound and a method of producing the organic silicon compound.

  提供以下式(I)的有机硅化合物：（其中，R1到R20分别独立表示烷基、烷氧基、芳氧基、环烷基、烷基环烷基、芳基、二烷基氨基或类似物，芳氧基和芳基可被从烷基、烷氧基和烷氧基中选择的取代基所取代。）该化合物可用于抑制有机材料在成型过程中的着色和热降解，以及含有该有机硅化合物的有机材料组合物和生产该有机硅化合物的方法。
• POLYORGANOSILOXANE COMPOUND, METHOD FOR PREPARING THE SAME, AND COPOLYCARBONATE RESIN COMPRISING THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20160145187A1

  公开（公告）日：2016-05-26

  A polyorganosiloxane compound, a method of preparing the same, and a copolycarbonate resin comprising the same are disclosed. Particularly, a copolycarbonate resin, which may be applied to a variety of applications, and in particular, comprises a polyorganosiloxane compound used as an impact modifier, a modifier, or a comonomer of a copolycarbonate resin and has improved mechanical properties such as low-temperature impact strength, is disclosed.

  公开了一种聚有机硅氧烷化合物、其制备方法以及包含该化合物的共聚碳酸酯树脂。特别地，公开了一种共聚碳酸酯树脂，可应用于各种应用中，特别是包含用作冲击改性剂、改性剂或共聚碳酸酯树脂的共聚物的共聚碳酸酯树脂，并具有改善的机械性能，如低温冲击强度的聚有机硅氧烷化合物。
• Sulfonated polyaryletherketone-block-polyethersulfone copolymers
  申请人：Brunelle Daniel Joseph

  公开号：US20080004443A1

  公开（公告）日：2008-01-03

  Sulfonated block copolymer suitable for use as proton exchange membranes for fuel cells comprise sulfonated polyaryletherketone blocks and polyethersulfone blocks. The sulfonated polyaryletherketone blocks comprise structural units of formula I wherein R 1 is C 1 -C 10 alkyl, C 3 -C 12 cycloalkyl, C 6 -C 14 aryl, allyl, alkenyl, alkoxy, halo, or cyano; Ar 1 and Ar 2 are each independently C 6 -C 20 aromatic radicals, or Ar 1 and Ar 2 , taken together with an intervening carbon atom, form a bicyclic C 6 -C 20 aromatic radical or a tricyclic C 6 -C 20 aromatic radical; M is H, a metal cation, a non-metallic inorganic cation, an organic cation or a mixture thereof; and a is 0 or an integer from 1 to 4.

  适用于燃料电池质子交换膜的磺化嵌段共聚物包括磺化聚芳醚酮嵌段和聚醚砜嵌段。磺化聚芳醚酮嵌段包括以下结构单位I的结构单元，其中R1是C1-C10烷基，C3-C12环烷基，C6-C14芳基，烯丙基，烯烷基，烷氧基，卤素或氰基；Ar1和Ar2分别是C6-C20芳香基，或Ar1和Ar2连同一个介于碳原子形成一个双环C6-C20芳香基或三环C6-C20芳香基；M为H，金属阳离子，非金属无机阳离子，有机阳离子或它们的混合物；a为0或1至4之间的整数。

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