2-(2-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)acetamido)-2-methyl-N-(4-morpholinophenyl)propanamide | 1273331-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(2-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)acetamido)-2-methyl-N-(4-morpholinophenyl)propanamide
• CAS: 1273331-02-4
• 化学式: C₃₂H₃₄N₄O₅
• 分子量: 554.646
• InChiKey: KISKJNZRPLWYDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  41.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  99.26
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  苯酐 以 甲醇 为溶剂， 生成 2-(2-(1,3-dioxoisoindolin-2-yl)-N-(4-methylbenzyl)acetamido)-2-methyl-N-(4-morpholinophenyl)propanamide
  参考文献：
  名称：

  A parallel Ugi reaction at students laboratories in the Ural and Moscow

  摘要：

  A four-component Ugi reaction was adapted for students education. To this end, a series of almost odorless aromatic isonitriles with donor substituents was reacted with a specific carboxylic acid, phthaloyl glycine, to obtain poorly soluble (although nicely crystallized) products. The process was performed and compared in two versions by using (1) a standard centrifuge for parallel separation of precipitates and (2) parallel filtration with SynCore apparatus. It is shown for a broad series of aliphatic ketones and benzyl amines that the yields are satisfactory and the products require no further purification.

  DOI：

  10.1134/s1070363210120303