2,6-Dimethyl-L-tyrosyl-D-alanyl-L-phenylalanyl-L-phenylalaninamide | 171807-62-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,6-Dimethyl-L-tyrosyl-D-alanyl-L-phenylalanyl-L-phenylalaninamide
• 英文别名: (2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanamide
• CAS: 171807-62-8
• 化学式: C₃₂H₃₉N₅O₅
• 分子量: 573.7
• InChiKey: BIKPLGOOJKDROD-VKKANWSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  177
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• MEDICINAL USES OF MU-OPIOID RECEPTOR AGONISTS
  申请人：CORNELL RESEARCH FOUNDATION, INC.

  公开号：EP1303186A2

  公开（公告）日：2003-04-23
• EP1303186A4
  申请人：——

  公开号：EP1303186A4

  公开（公告）日：2007-02-07
• Medicinal uses of mu-opioid receptor agonists
  申请人：——

  公开号：US20040029796A1

  公开（公告）日：2004-02-12

  The present invention provides methods for stimulating a mu-opioid receptor agonist peptide in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two &agr;-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-&agr;-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.
• Medicinal Uses of Mu-Opioid Receptor Agonists
  申请人：Szeto Hazel

  公开号：US20070027070A1

  公开（公告）日：2007-02-01

  The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two α-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-α-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.
• US7498297B2
  申请人：——

  公开号：US7498297B2

  公开（公告）日：2009-03-03