(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-3-phenyl-propionylamino}-propionylamino)-4-carboxy-butyrylamino]-succinic acid | 141664-70-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-3-phenyl-propionylamino}-propionylamino)-4-carboxy-butyrylamino]-succinic acid
• CAS: 141664-70-2
• 化学式: C₃₅H₄₆N₆O₁₁
• 分子量: 726.784
• InChiKey: QLCHACUJRLFVIA-VZPLKPGNSA-N

物化性质

• 沸点：
  1153.3±65.0 °C(Predicted)
• 密度：
  1.322±0.06 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  Boc-VFFAE(Bzl)D(Bzl)-OH 生成 (S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-3-phenyl-propionylamino}-propionylamino)-4-carboxy-butyrylamino]-succinic acid
  参考文献：
  名称：

  Synthesis of a protected peptide corresponding to residues 1-25 of the .beta.-amyloid protein of Alzheimer's disease

  摘要：

  The deposition of proteinaceous amyloid plaque in the brain is a characteristic of Alzheimer's disease. These plaques are composed of the 42 amino acid beta-amyloid protein (beta-A4), the sequence of which has been determined. beta-A4 is deposited in the brain as a noncrystalline, fibrous aggregate containing regular structure. Detailed structural studies of the beta-A4 aggregate require pure beta-A4 and various labeled analogs and sequence analogs. A convergent synthetic route to the beta-A4 protein has been designed to meet this need. This paper reports the synthesis, by solid-phase fragment coupling, of a 25-residue protected peptide corresponding to residues 1-25 of beta-A4. This peptide was prepared from four protected fragments which were coupled sequentially on the Kaiser oxime resin. Deprotection of the intermediate fragments led to the discovery of aspartimide formation at one site. The protection strategy and the deprotection conditions were adjusted to eliminate the undesired rearrangement.

  DOI：

  10.1021/jo00038a034