5-Benzoyl-8a-hydroxy-3,3-diphenyl-2,4-dihydro-1,4-benzoxazin-8-one | 219321-19-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 5-Benzoyl-8a-hydroxy-3,3-diphenyl-2,4-dihydro-1,4-benzoxazin-8-one
• CAS: 219321-19-4
• 化学式: C₂₇H₂₁NO₄
• 分子量: 423.468
• InChiKey: XBWPMADEZJJZNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-Benzoyl-8a-hydroxy-3,3-diphenyl-2,4-dihydro-1,4-benzoxazin-8-one 以 甲醇 为溶剂， 反应 0.5h， 生成 [8-(3-Methylbutylamino)-3,3-diphenyl-2,4-dihydro-1,4-benzoxazin-5-yl]-phenylmethanone
  参考文献：
  名称：

  Synthesis and in Vitro Evaluation of New 8-Amino-1,4-benzoxazine Derivatives as Neuroprotective Antioxidants

  摘要：

  A series of new 8-amino-1,4-benzoxazine derivatives 5a-o was synthesized and examined for their intrinsic cytotoxicity and their capacity to inhibit oxidative stress-mediated neuronal degeneration in neuronal cell cultures. In particular, substituent effects at the 3- and 8-positions of the 1,4-benzoxazine ring were investigated by in vitro evaluation.. In this aim, 3-alkyl substituents seemed to be essential for efficient neuroprotective activity. Furthermore, within the subseries of substituted S-alkyl benzoxazines, the most active derivatives were those bearing an 8-benzylamino substituent. From the combined results of both toxicity and neuroprotection expressed in terms of the safety index, 8-benzylamino-substituted-3-alkyl-1,4-benzoxazines were identified as the most promising compounds, owing to their potent neuroprotective activity without the manifestation of intrinsic cytotoxicity.

  DOI：

  10.1021/jm991105j
• 作为产物：
  描述：

  2-氨基-2,2-二苯基-1-乙醇 、 (3,4-dihydroxy-2-methoxyphenyl) (phenyl) methanone 在 高氯酸四乙基铵 作用下， 以 甲醇 为溶剂， 以75%的产率得到5-Benzoyl-8a-hydroxy-3,3-diphenyl-2,4-dihydro-1,4-benzoxazin-8-one
  参考文献：
  名称：

  A convenient two-step one-pot electrochemical synthesis of novel 8-amino-1,4-benzoxazine derivatives possessing anti-stress oxidative properties

  摘要：

  Using (3,4-hydroxy-2-methoxyphenyl) (phenyl) methanone as the starting material, the reaction of the electrogenerated 3,4-quinone with amino alcohols leads to the transient 1,4-benzoxazin-8-one species. The latter can undergo a subsequent addition reaction of an amine at the 8-position affording, after electrochemical reduction, novel 8-amino-1,4-benzoxazine derivatives. The entire sequence can be conducted in one-pot, without isolation of intermediates. (C),1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02037-1