6-amino-4-[(3-bromophenyl)amino]-7-(4-{N-[(ethoxycarbonyl)methyl]-N-methylamino}butyloxy)-quinazoline | 290303-25-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-amino-4-[(3-bromophenyl)amino]-7-(4-{N-[(ethoxycarbonyl)methyl]-N-methylamino}butyloxy)-quinazoline
• 英文别名: Ethyl 2-[4-[6-amino-4-(3-bromoanilino)quinazolin-7-yl]oxybutyl-methylamino]acetate
• CAS: 290303-25-2
• 化学式: C₂₃H₂₈BrN₅O₃
• 分子量: 502.411
• InChiKey: AFPIFOQCAQUYDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES
  申请人：Boehringer Ingelheim Pharma KG

  公开号：EP1157011A1

  公开（公告）日：2001-11-28
• US6972288B1
  申请人：——

  公开号：US6972288B1

  公开（公告）日：2005-12-06
• [EN] 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES<br/>[FR] DERIVES DE 4-AMINO-QUINAZOLINE ET DE QUINOLINE AYANT UN EFFET INHIBITEUR SUR LA TRANSDUCTION DE SIGNAL PAR LES TYROSINE KINASES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2000051991A1

  公开（公告）日：2000-09-08

  The present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.