| 1548128-00-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 1548128-00-2
• 化学式: C₁₅H₁₂O₆
• 分子量: 288.257
• InChiKey: KYXHVAXYBHICBE-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin 在 叔丁基过氧化氢 、 selenium(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 生成 、 5-(3'-methyl-4'-hydroxy-2'-butenoxy)-6,7-methylendioxycoumarin
  参考文献：
  名称：

  Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

  摘要：

  Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 mu M, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 mu M, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.12.104