2-methyl-3-(methylthio)furan sulphone | 1001076-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-methyl-3-(methylthio)furan sulphone
• 英文别名: 2-methyl-3-(methylsulfonyl)furan；3-Methanesulfonyl-2-methylfuran；2-methyl-3-methylsulfonylfuran
• CAS: 1001076-80-7
• 化学式: C₆H₈O₃S
• 分子量: 160.194
• InChiKey: DQPSWDYHWQZIKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-3-(methylthio)furan sulphone 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.03h， 以1.0 g的产率得到5-Bromo-2-methyl-3-methylsulfonylfuran
  参考文献：
  名称：

  BENZIMIDAZOLE CANNABINOID AGONISTS BEARING A SUBSTITUTED HETEROCYCLIC GROUP

  摘要：

  本发明涉及具有大麻素受体激动性质的新型苯并咪唑化合物（I）的公式，包括这些化合物的药物组合物，制备这些化合物的化学过程以及它们在治疗与大麻素受体在动物中介导相关的疾病，特别是人类中的用途。

  公开号：

  US20130324529A1
• 作为产物：
  描述：

  2-甲基-3-甲硫基呋喃 在 二乙二醇二丁醚 、 氧气 作用下， 反应 20.0h， 以80%的产率得到2-methyl-3-(methylthio)furan sulphone
  参考文献：
  名称：

  在清洁条件下用分子氧选择性氧化（杂）硫化物

  摘要：

  为将单一原材料转化为独特的高价值产品而开发的生态友好型和可转换催化系统的开发是一个特别吸引人的概念，也是一项艰巨的合成挑战。在本工作中，建立了在清洁条件下使用分子氧将硫化物有效选择性氧化为砜和亚砜的第一个实例。

  DOI：

  10.1039/c9gc03713f

文献信息

• 5-Membered heterocyclic compound
  申请人：Nishida Haruyuki

  公开号：US20090156642A1

  公开（公告）日：2009-06-18

  The present invention provides 5-membered heterocycle compounds represented by the following general formula (I): The present compounds have a superior acid secretion inhibitory effect, and shows an antiulcer activity and the like.

  本发明提供了以下通式(I)表示的5元杂环化合物： 本化合物具有优异的抑制胃酸分泌效果，并显示出抗溃疡活性等。
• Pyrrole compounds
  申请人：Kajino Masahiro

  公开号：US20080262042A1

  公开（公告）日：2008-10-23

  The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity, which is represented by the formula (I) wherein R 1 is an optionally substituted cyclic group, R 2 is a substituent, R 3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R 4 and R 5 are each a hydrogen atom, an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R 6 and R 6′ are each a hydrogen atom or an alkyl group, and n is an integer of 0-3, or a salt thereof.

  本发明提供了一种具有优异的抑制酸分泌作用和显示抗溃疡活性的化合物，其由式（I）表示，其中R1是一个可选取代的环烷基，R2是一个取代基，R3是一个可选取代的烷基、酰基、可选取代的羟基、可选取代的氨基、卤素原子、氰基或硝基，R4和R5分别是氢原子、可选取代的烷基、酰基、可选取代的羟基、可选取代的氨基、卤素原子、氰基或硝基，R6和R6'分别是氢原子或烷基，n为0-3的整数，或其盐。
• PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF
  申请人：Hollingsworth Rawle I.

  公开号：US20080146458A1

  公开（公告）日：2008-06-19

  Substituted oxazolidinone of the formula: wherein R 2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.

  描述了以下化学式的氧杂环丙酮类替代物：其中R2是选择自甲基，乙基和异丙基基团的烷基。这些化合物具有抗菌作用。
• WO2008/3665
  申请人：——

  公开号：——

  公开（公告）日：——
• Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver
  作者：Brian G. Lake、Roger J. Price、David G. Walters、John C. Phillips、Philip J. Young、Timothy B. Adams

  DOI：10.1016/s0278-6915(03)00213-8

  日期：2003.12

  The metabolism of two thiofurans, namely furfuryl mercaptan (FM) and 2-methyl-3-furanthiol (MTF), to their corresponding methyl sulphide and methyl sulphoxide derivatives has been studied in male Sprague-Dawley rat hepatocytes and liver microsomes. Rat hepatocytes converted FM to furfuryl methyl sulphoxide (FMSO) and MTF to 2-methyl-3-(methylthio)furan sulphoxide (MMFSO). Liver microsomes catalysed the NADPH-dependent metabolism of furfuryl methyl sulphide (FMS) to FMSO and 2-methyl-3-(methylthio)furan sulphide (MMFS) to MMFSO. FMS and MMFS metabolism to their thiofuran methyl sulphoxide derivatives was induced by the treatment of rats with Aroclor 1254 and inhibited in liver microsomes treated with I-aminobenzotriazole. The NADPH-dependent metabolism of FM to FMSO and MTF to MMFSO in liver microsomes was observed in the presence of S-adenosylmethionine. In summary, both thiofurans can be metabolised in rat liver to their thiofuran methyl sulphide derivatives which can be subsequently S-oxidised to form thiofuran methyl sulphoxides. FM and MTF appear to be substrates for rat hepatic microsomal thiol methyltransferase and the S-oxidation of FMS and MMFS appears to be primarily catalysed by cytochrome P450 forms. (C) 2003 Elsevier Ltd. All rights reserved.