di-(2-((phenylimino)methyl)phenolato-κ²-N,O)platinum(II) | 90759-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di-(2-((phenylimino)methyl)phenolato-κ²-N,O)platinum(II)
• 英文别名: trans-bis[2-(phenyliminomethyl)phenolato-N,O]platinum(II)
• CAS: 90759-53-8；1609163-53-2
• 化学式: C₂₆H₂₀N₂O₂Pt
• 分子量: 587.537
• InChiKey: ZBTIJADVBKQTLR-XGNDVENUSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  亚水杨基苯胺 、 [PtCl2(cis-cyclooctene)]2 在 正丁基锂 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 26.0h， 以82%的产率得到di-(2-((phenylimino)methyl)phenolato-κ²-N,O)platinum(II)
  参考文献：
  名称：

  Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes

  摘要：

  Twelve new (salicylaldiminato) platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. Initial biotesting was done on platinum complexes 1-6, which display a wide range of physicochemical properties. Whereas introduction of aromatic rings in the complexes did not seem to have a significant impact on bioactivities, the length of the aliphatic group positively correlated with cytotoxicity in all cell lines. Complexes 2 and 3 were found to be particularly potent against LN18 cells as demonstrated by stronger cell growth inhibition when compared to cisplatin. These initial findings led us to develop an additional series of mono (salicylaldiminato) platinum(II) complexes 7-12, which were subjected to additional cytotoxicity studies but were less cytotoxic compared to the bis Schiff base complexes. These organometallic compounds could serve as interesting starting points for the development of novel therapeutic strategies to treat brain tumors. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.02.028

文献信息

• Syntheses, structures, and solid-state phosphorescence characteristics of trans-bis(salicylaldiminato)Pt(II) complexes bearing perpendicular N-aryl functionalities
  作者：Shotaro Iwata、Hidenori Takahashi、Asami Ihara、Kumiko Hiramatsu、Junya Adachi、Soichiro Kawamorita、Naruyoshi Komiya、Takeshi Naota

  DOI：10.1007/s11243-017-0198-9

  日期：2018.3

  The syntheses, structures, and solid-state emission characteristics of trans-bis(salicylaldiminato)Pt(II) complexes bearing N-aromatic functionalities are described herein. A series of Pt complexes bearing various N-phenyl (1) and N-(1-naphthyl) (2) groups on the salicylaldiminato ligands were prepared by reacting PtCl2(CH3CN)2 with the corresponding N-salicylidene aromatic amines, and the trans-coordination

  本文描述了具有 N-芳族官能团的反式双(水杨醛基二氨基)Pt(II) 配合物的合成、结构和固态发射特性。通过 PtCl2(CH3CN)2 与相应的 N-水杨亚芳胺反应制备了一系列在水杨醛二氨基配体上带有各种 N-苯基 (1) 和 N-(1-萘基) (2) 基团的 Pt 配合物，反式这些配合物的配位和晶体堆积是基于 X 射线衍射 (XRD) 明确确定的。在 N 原子上具有 2,6-二甲基苯基 (1c)、2,6-二异丙基苯基 (1d)、1-萘基 (2a) 和 1-(2-甲基萘基) (2b) 基团的配合物在环境温度下表现出强烈的磷光发射处于结晶状态，而具有苯基 (1a)、2,6-二溴苯基 (1b) 和 2,6-双(N, N-二甲氨基)苯基(1e)官能团在相同条件下发射性较低或不发射。XRD 分析确定了 1c、1d 和 2a 的发光晶体中 N-芳基官能团的 Pt 和 H 原子之间的显着分子内相互作
• Syamal, A.; Gupta, B. K., Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 1984, vol. 23, # 3, p. 260 - 261
  作者：Syamal, A.、Gupta, B. K.

  DOI：——

  日期：——