(2S)-2-azaniumyl-3-(4-chloro-2-fluorophenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-azaniumyl-3-(4-chloro-2-fluorophenyl)propanoate
• 化学式: C9H9ClFNO2
• 分子量: 217.62
• InChiKey: ZPMGQOHZMMWUAT-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• EP1622618A1
  申请人：——

  公开号：EP1622618A1

  公开（公告）日：2006-02-08
• EP1622618A4
  申请人：——

  公开号：EP1622618A4

  公开（公告）日：2008-08-27
• [EN] MELANOCORTIN RECEPTOR-SPECIFIC COMPOUNDS<br/>[FR] COMPOSES SPECIFIQUES DU RECEPTEUR DE LA MELANOCORTINE
  申请人：PALATIN TECHNOLOGIES INC

  公开号：WO2004098602A1

  公开（公告）日：2004-11-18

  A melanocortin receptor-specific compound of the general formula of structure (I): where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
• [EN] MC4-R AGONISTS FOR THE TREATMENT OF OBESITY<br/>[FR] AGONISTES DE MC4-R POUR LE TRAITEMENT DE L'OBÉSITÉ
  申请人：PALATIN TECHNOLOGIES INC

  公开号：WO2009144432A1

  公开（公告）日：2009-12-03

  Methods for selection of compounds for treatment of obesity, compounds selected by the disclosed methods, and methods of treatment of obesity, wherein a selective melanocortin-4 receptor compound is identified, which compound is further characterized in that it attenuates the binding of both an agonist, including alpha-melanocyte stimulating hormone, and an inverse agonist, including agouti-related protein, to a melanocortin receptor, including melanocortin-4 receptor.