3-((4-(benzyloxy)-4-oxobutyl)dimethyl ammonio)propane-1-sulfonate | 1349808-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((4-(benzyloxy)-4-oxobutyl)dimethyl ammonio)propane-1-sulfonate
• 英文别名: 3-[Dimethyl-(4-oxo-4-phenylmethoxybutyl)azaniumyl]propane-1-sulfonate
• CAS: 1349808-78-1
• 化学式: C₁₆H₂₅NO₅S
• 分子量: 343.444
• InChiKey: MQUXJHRXPMVNJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  91.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-((4-(benzyloxy)-4-oxobutyl)dimethyl ammonio)propane-1-sulfonate 在 palladium 10% on activated carbon 盐酸 、 氢气 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 20.0 ℃ 、275.8 kPa 条件下， 反应 3.0h， 生成 3-[Dimethyl-[4-oxo-4-(2,3,4,5,6-pentafluorophenoxy)butyl]azaniumyl]propane-1-sulfonate
  参考文献：
  名称：

  [EN] ZWITTERIONIC REAGENTS
  [FR] RÉACTIFS ZWITTERIONIQUES

  摘要：

  公开号：

  WO2011146595A3
• 作为产物：
  描述：

  4-(二甲胺基)丁酸 盐酸盐 在 2,6-二叔丁基吡啶 、 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 3.0h， 生成 3-((4-(benzyloxy)-4-oxobutyl)dimethyl ammonio)propane-1-sulfonate
  参考文献：
  名称：

  [EN] ZWITTERIONIC REAGENTS
  [FR] RÉACTIFS ZWITTERIONIQUES

  摘要：

  公开号：

  WO2011146595A3

文献信息

• Zwitterionic reagents for labeling, cross-linking and improving the performance of chemiluminescent immunoassays
  作者：Anand Natrajan、David Sharpe、David Wen

  DOI：10.1039/c2ob06807a

  日期：——

  Improving reagent performance in immunoassays both to enhance assay sensitivity and to minimize interference are ongoing challenges in clinical diagnostics. We describe herein the syntheses of a new class of hydrophilic reagents containing sulfobetaine zwitterions and their applications. These zwitterionic reagents are potentially useful for improving the properties of immunoassay reagents. We demonstrate

  改善免疫测定中的试剂性能以增强测定灵敏度并最小化干扰是临床诊断中的持续挑战。我们在这里描述了新型的亲水性试剂的合成磺基甜菜碱两性离子及其应用。这些两性离子试剂可潜在地用于改善免疫测定试剂的性能。我们首次证明，两性离子标记是减少蛋白质与微粒的非特异性结合并提高疏水性肽的水溶性的通用且可行的策略。我们还描述了两性离子交联剂的合成，并证明了其用于肽缀合的效用。在自动化的化学发光免疫分析中，疏水性小分析物的检测性能得到了改善（茶碱）使用 cri啶酯 与a共轭 两性离子磺基甜菜碱 链接器与 六乙二醇链接器。两种大型分析物（甲状腺刺激激素）的夹心测定性能相似cri啶酯标签。这些结果表明两性离子在改善水溶性和减少化学发光的非特异性结合方面与聚乙二醇互补。cri啶酯 共轭物。
• Bioorthogonal “Click and Release” Reaction‐Triggered Aggregation of Gold Nanoparticles Combined with Released Lonidamine for Enhanced Cancer Photothermal Therapy
  作者：Xiao Yan、Ke Li、Tian‐Qiu Xie、Xiao‐Kang Jin、Cheng Zhang、Qian‐Ru Li、Jun Feng、Chuan‐Jun Liu、Xian‐Zheng Zhang

  DOI：10.1002/anie.202318539

  日期：2024.3.22

  Cancer has been the most deadly disease, and 13 million cancer casualties are estimated to occur each year by 2030. Gold nanoparticles (AuNPs)‐based photothermal therapy (PTT) has attracted great interest due to its high spatiotemporal controllability and noninvasiveness. Due to the trade‐off between particle size and photothermal efficiency of AuNPs, rational design is needed to realize aggregation of AuNPs into larger particles with desirable NIR adsorption in tumor site. Exploiting the bioorthogonal “Click and Release” (BCR) reaction between iminosydnone and cycloalkyne, aggregation of AuNPs can be achieved and attractively accompanied by the release of chemotherapeutic drug purposed to photothermal synergizing. We synthesize iminosydnone‐lonidamine (ImLND) as a prodrug and choose dibenzocyclooctyne (DBCO) as the trigger of BCR reaction. A PEGylated AuNPs‐based two‐component nanoplatform consisting of prodrug‐loaded AuNPs‐ImLND and tumor‐targeting peptide RGD‐conjugated AuNPs‐DBCO‐RGD is designed. In the therapeutic regimen, AuNPs‐DBCO‐RGD are intravenously injected first for tumor‐specific enrichment and retention. Once the arrival of AuNPs‐ImLND injected later at tumor site, highly photothermally active nanoaggregates of AuNPs are formed via the BCR reaction between ImLND and DBCO. The simultaneous release of lonidamine further enhanced the therapeutic performance by sensitizing cancer cells to PTT.
• [EN] ZWITTERIONIC REAGENTS<br/>[FR] RÉACTIFS ZWITTERIONIQUES
  申请人：SIEMENS HEALTHCARE DIAGNOSTICS

  公开号：WO2011146595A3

  公开（公告）日：2012-01-12