| 1239978-08-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• CAS: 1239978-08-5
• 化学式: C₄₃H₈₆N₂O₇
• 分子量: 743.165
• InChiKey: DIQOMBUKOSCMQE-ZESVVUHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.83
• 重原子数：
  52.0
• 可旋转键数：
  35.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  104.35
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 乙醚 为溶剂， 以100%的产率得到LysinolL
  参考文献：
  名称：

  Formation of Silica Precipitates on Membrane Surfaces in Two and Three Dimensions

  摘要：

  Ether lipids with alkyl chains of uniform length and varying amine headgroups were synthesized and assembled into bilayer structures in aqueous solution, which served as templates for the formation of silica in two and three dimensions produced under ambient conditions. Dynamic light scattering revealed that unilamellar vesicles of the aminolipids are formed by the extrusion method. The alkylation of the polar amine headgroup was systematically increased from a primary, secondary, and tertiary amine to a quaternary ammonium salt, and the amount of silica was quantified by the beta-silicomolybdate method as a function of the headgroup. A lysinol-connected ether lipid harboring two primary amine groups was also investigated. This variation enabled us to compare the influence of the headgroup on the properties of the precipitated silica in detail. By spreading of unilamellar aminolipid vesicles onto planar silicon substrates, two-dimensional planar bilayers can be produced. By means of ellipsometry in conjunction with atomic force microscopy, we were able to demonstrate that very thin silica layers with a thickness of a few nanometers are formed within minutes on the surface of the aminolipid bilayers. All layers are composed of silica nanospheres, and the thickness turned out to be independent of the amine headgroup.

  DOI：

  10.1021/la1021627
• 作为产物：
  描述：

  (R)-2,3-bis(dodecyloxy)propyl trifluoromethane sulfonate 、 di-tert-butyl (6-hydroxyhexane-1,5-diyl)(S)-dicarbamate 在 sodium hydride 作用下， 以75%的产率得到
  参考文献：
  名称：

  Formation of Silica Precipitates on Membrane Surfaces in Two and Three Dimensions

  摘要：

  Ether lipids with alkyl chains of uniform length and varying amine headgroups were synthesized and assembled into bilayer structures in aqueous solution, which served as templates for the formation of silica in two and three dimensions produced under ambient conditions. Dynamic light scattering revealed that unilamellar vesicles of the aminolipids are formed by the extrusion method. The alkylation of the polar amine headgroup was systematically increased from a primary, secondary, and tertiary amine to a quaternary ammonium salt, and the amount of silica was quantified by the beta-silicomolybdate method as a function of the headgroup. A lysinol-connected ether lipid harboring two primary amine groups was also investigated. This variation enabled us to compare the influence of the headgroup on the properties of the precipitated silica in detail. By spreading of unilamellar aminolipid vesicles onto planar silicon substrates, two-dimensional planar bilayers can be produced. By means of ellipsometry in conjunction with atomic force microscopy, we were able to demonstrate that very thin silica layers with a thickness of a few nanometers are formed within minutes on the surface of the aminolipid bilayers. All layers are composed of silica nanospheres, and the thickness turned out to be independent of the amine headgroup.

  DOI：

  10.1021/la1021627