4-chloro-6-methyl-2-methylsulfanyl-5-propylpyrimidine | 30150-62-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-chloro-6-methyl-2-methylsulfanyl-5-propylpyrimidine
• CAS: 30150-62-0
• 化学式: C₉H₁₃ClN₂S
• 分子量: 216.735
• InChiKey: HXYWVGAVZUGBQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-chloro-6-methyl-2-methylsulfanyl-5-propylpyrimidine 在 sodium hydride 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 反应 10.25h， 生成 4-benzyloxy-6-methyl-2-methylsulfonyl-5-propylpyrimidine
  参考文献：
  名称：

  [EN] PTPN2 INHIBITORS
  [FR] INHIBITEURS DE PTPN2

  摘要：

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.

  公开号：

  WO2023220572A1
• 作为产物：
  描述：

  6-methyl-2-(methylthio)-5-propylpyrimidin-4(3H)-one 在 三氯氧磷 作用下， 以98 %的产率得到4-chloro-6-methyl-2-methylsulfanyl-5-propylpyrimidine
  参考文献：
  名称：

  [EN] PTPN2 INHIBITORS
  [FR] INHIBITEURS DE PTPN2

  摘要：

  The present invention is generally directed to inhibitors of protein tyrosine phosphatase enzymes (PTPN1 and/or PTPN2) useful in the treatment of diseases and disorders modulated by said enzymes and having the Formula (I). Further disclosed a method of treating a disease or disorder associated with PTPN1/PTPN2, comprising of administering to a subject a compound or a pharmaceutical composition.

  公开号：

  WO2023220572A1

文献信息

• [EN] BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE<br/>[FR] BENZOXAZÉPINES EN TANT QU'INHIBITEURS DE PI3K/MTOR ET PROCÉDÉS DE LEURS UTILISATION ET FABRICATION
  申请人：EXELIXIS INC

  公开号：WO2012071501A1

  公开（公告）日：2012-05-31

  The invention is directed to inhibitors of mTOR and pharmaceutically acceptable salts or solvates thereof, as well as methods of using them. The inhibitors are generally of structural formula I and pharmaceutically acceptable salts thereof, wherein the variables are as defined herein.

  这项发明涉及 mTOR 的抑制剂及其药用盐或溶剂化物，以及它们的使用方法。这些抑制剂通常具有结构式 I 及其药用盐，其中变量如本文所定义。
• BENZOXAZEPINES AS INHIBITORS OF P13K/mTOR AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：Exelixis, Inc.

  公开号：EP2643315A1

  公开（公告）日：2013-10-02