cis-{2-(4-(tert-butyloxycarbonyl)butyl)malonate diamine platinum(II)} | 150344-81-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: cis-{2-(4-(tert-butyloxycarbonyl)butyl)malonate diamine platinum(II)}
• CAS: 150344-81-3
• 化学式: C₁₂H₂₄N₂O₆Pt
• 分子量: 487.412
• InChiKey: LPUPUAZFZNOMIB-UHFFFAOYSA-L

反应信息

• 作为反应物：
  描述：

  cis-{2-(4-(tert-butyloxycarbonyl)butyl)malonate diamine platinum(II)} 、 三氟乙酸 以 水 为溶剂， 以55%的产率得到1,1,5-Pentanetricarboxylic acid, platinum(4+) salt, ammoniate (1:1:2)
  参考文献：
  名称：

  Platinum(II) complexes of functionalized malonato ligands: unequivocal synthesis, interaction with a tetradeoxyribonucleotide and deoxyribonucleic acid

  摘要：

  The unequivocal syntheses of four cis-[PtL2{(O2C)2CH(CH2)nCO2H}] complexes [L2 = (NH3)2 or trans-cyclohexane-1,2-diamine, n = 1 or 4] has been achieved, avoiding any interaction between the pendant carboxyl group and the platinum. The complexes have been characterized by elemental analysis, C-13 NMR and FAB mass spectroscopy. Their interaction with a tetradeoxyribonucleotide d(T-G-G-T) (G = guanosine, T = ribosylthymine) and DNA (in vitro) has been investigated to show that they form adducts of the type [PtL2{(GpG)-N7,N7'}] as do the known therapeutically active platinum complexes. However the presence of the free carboxyl function increases significantly the reactivity with respect to that of the related non-functionalized malonato complexes [PtL2{H2C(CO2)2}].

  DOI：

  10.1039/dt9930002141
• 作为产物：
  描述：

  {2-(4-(tert-butyloxycarbonyl)butyl)malonate bis(dimethylsulfoxide) platinum(II)} 在 氨 作用下， 以 not given 为溶剂， 以70%的产率得到cis-{2-(4-(tert-butyloxycarbonyl)butyl)malonate diamine platinum(II)}
  参考文献：
  名称：

  Platinum(II) complexes of functionalized malonato ligands: unequivocal synthesis, interaction with a tetradeoxyribonucleotide and deoxyribonucleic acid

  摘要：

  The unequivocal syntheses of four cis-[PtL2{(O2C)2CH(CH2)nCO2H}] complexes [L2 = (NH3)2 or trans-cyclohexane-1,2-diamine, n = 1 or 4] has been achieved, avoiding any interaction between the pendant carboxyl group and the platinum. The complexes have been characterized by elemental analysis, C-13 NMR and FAB mass spectroscopy. Their interaction with a tetradeoxyribonucleotide d(T-G-G-T) (G = guanosine, T = ribosylthymine) and DNA (in vitro) has been investigated to show that they form adducts of the type [PtL2{(GpG)-N7,N7'}] as do the known therapeutically active platinum complexes. However the presence of the free carboxyl function increases significantly the reactivity with respect to that of the related non-functionalized malonato complexes [PtL2{H2C(CO2)2}].

  DOI：

  10.1039/dt9930002141