1,8-Dihydroxy-6H-dibenzo[c, h]chromene-12-carbonitrile | 550399-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 1,8-Dihydroxy-6H-dibenzo[c, h]chromene-12-carbonitrile
• 英文别名: 1,8-dihydroxy-6H-naphtho[1,2-c]isochromene-12-carbonitrile
• CAS: 550399-76-3
• 化学式: C₁₈H₁₁NO₃
• 分子量: 289.29
• InChiKey: AHTDNHBFJVCWOA-UHFFFAOYSA-N

物化性质

• 沸点：
  646.0±55.0 °C(Predicted)
• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  73.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION
  申请人：CHANG Chien-Neng

  公开号：US20090010884A1

  公开（公告）日：2009-01-08

  The present invention provides compositions and methods for preventing, treating, or inhibiting inflammatory diseases, disorders, or conditions of the skin, and diseases, disorders, or conditions associated with collagen depletion using one or more estrogenic agents.

  本发明提供了使用一个或多个雌激素类药物预防、治疗或抑制皮肤炎症性疾病、紊乱或状况以及与胶原蛋白流失相关的疾病、紊乱或状况的组合物和方法。
• SUBSTITUTED 6H-DIBENZO C,H]CHROMENES AS ESTROGENIC AGENTS
  申请人：Wyeth

  公开号：EP1453820A1

  公开（公告）日：2004-09-08
• SUBSTITUTED 6H-DIBENZO[C,H]CHROMENES AS ESTROGENIC AGENTS
  申请人：Wyeth

  公开号：EP1453820B1

  公开（公告）日：2005-06-01
• [EN] SUBSTITUTED 6H-DIBENZO[c,h]CHROMENES AS ESTROGENIC AGENTS<br/>[FR] 6H-DIBENZO[C,H]CHROMENES SUBSTITUES COMME SUBSTANCES OESTROGENIQUES
  申请人：WYETH CORP

  公开号：WO2003051863A1

  公开（公告）日：2003-06-26

  This invention provides estrogen receptor modulators of formula (I), having the structure, wherein R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
• [EN] PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ET PROCÉDÉS POUR PRÉVENIR, TRAITER OU INHIBER DES MALADIES, DES TROUBLES OU DES AFFECTIONS INFLAMMATOIRES CUTANÉS ET DES MALADIES, DES TROUBLES OU DES AFFECTIONS ASSOCIÉS À UN APPAUVRISSEMENT EN COLLAGÈNE
  申请人：WYETH CORP

  公开号：WO2009009417A2

  公开（公告）日：2009-01-15

  The present invention provides compositions and methods for preventing, treating, or inhibiting inflammatory diseases, disorders, or conditions of the skin, and diseases, disorders, or conditions associated with collagen depletion using one or more estrogenic agents.