(9S)-9-Hydroxy-6'-methoxycinchonanium lactate | 85135-84-8

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: (9S)-9-Hydroxy-6'-methoxycinchonanium lactate
• 英文别名: (S)-[(2R,4S,5R)-5-ethenyl-1-azoniabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;2-hydroxypropanoate
• CAS: 85135-84-8
• 化学式: C23H30N2O5
• 分子量: 414.5
• InChiKey: ZIDGEHZBXVXPFQ-VJAUXQICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.13
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SCHMELZEXTRUSION VON WIRKSTOFFSALZEN
  申请人：Röhm GmbH

  公开号：EP1478344B1

  公开（公告）日：2007-05-23
• Melt extrusion of salts of active ingredients
  申请人：——

  公开号：US20040253314A1

  公开（公告）日：2004-12-16

  The invention relates to a method for producing active ingredient-containing granules or powders involving the following steps: a) melting a mixture consisting of a pharmaceutical active ingredient and of a (meth)acrylate copolymer, which is comprised of 40 to 75 wt. % of radically polymerized C1 to C4 alkyl esters of acrylic acid or of methacrylic acid and can be comprised of 25 to 60 wt. % (meth)acrylate monomers having an anionic group in the alkyl radial; b) extruding the mixture, and; c) comminuting the extrudate to form a granule or powder. The inventive method is characterized in that the active ingredient is the salt of an alkaline substance, and in that the pH value, which can be measured on the obtained powder or granule, is equal to or less than pH 7.0. The invention also relates to pharmaceutical dosage forms or precursors thereof, which can be produced using the inventive method.
• US8642089B2
  申请人：——

  公开号：US8642089B2

  公开（公告）日：2014-02-04