1-(3-benzyl-2-imino-2,3-dihydro-benzoimidazol-1-yl)-3-phenoxy-propan-2-ol | 292639-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(3-benzyl-2-imino-2,3-dihydro-benzoimidazol-1-yl)-3-phenoxy-propan-2-ol
• 英文别名: 1-(3-benzyl-2-imino-2,3-dihydro-1H-benzimidazol-1-yl)-3-phenoxypropan-2-ol；1-(3-benzyl-2-iminobenzimidazol-1-yl)-3-phenoxypropan-2-ol
• CAS: 292639-66-8
• 化学式: C₂₃H₂₃N₃O₂
• 分子量: 373.455
• InChiKey: YLKDCSKJNOKCGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  567.1±60.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS FOR TREATING CANCER<br/>[FR] COMPOSÉS UTILISÉS POUR TRAITER LE CANCER
  申请人：EVOTEC AG

  公开号：WO2010067067A1

  公开（公告）日：2010-06-17

  Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterised by abnormal cell growth and/or dysregulated apoptosis.

  通式（I）的化合物：其中R1、R2、R3、R4、R5、R6、X和Y如本文所定义，是Bcl-2的抑制剂，可用于治疗以异常细胞生长和/或失调凋亡为特征的疾病。
• Small-molecule agonists for type-2 orexin receptor
  申请人：Yanagisawa Masashi

  公开号：US20140051700A1

  公开（公告）日：2014-02-20

  Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

  对于需要激活类型2俄雷兴受体（OX2R）的细胞的方法和组合物，包括（a）向受试者施用环状胍基氧雷兴受体激动剂，以及（b）检测由此产生的增强清醒或增加对饮食诱导的体脂积累的抵抗力，或缩短从全身麻醉或时差反应中恢复的方法。
• GUANIDINE COMPOUNDS AS ANESTHETICS AND FOR TREATMENT OF NERVOUS SYSTEM DISORDERS
  申请人：Drasner Kenneth

  公开号：US20110166181A1

  公开（公告）日：2011-07-07

  Novel guanidine compounds having the formula in which R1, R2 and R4 are as defined, are effective as sodium channel dockers in neuronal mammalian cells and as anesthetics and/or analgesics, particularly local spinal and/or epidural anesthetics, for alleviation of neuropathic pain, for providing a neuroprotective effect, and for producing anti-convulsant effects.

  具有以下结构式的新型胍类化合物，在神经元哺乳动物细胞中作为钠通道的停靠剂，并作为麻醉剂和/或镇痛剂，特别是局部脊髓和/或硬膜外麻醉剂，用于缓解神经病性疼痛，提供神经保护作用和产生抗惊厥作用，其中R1、R2和R4如定义。
• COMPOUNDS FOR TREATING CANCER
  申请人：East Stephen Peter

  公开号：US20110312969A1

  公开（公告）日：2011-12-22

  Compounds of general formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterised by abnormal cell growth and/or dysregulated apoptosis.

  通式（I）的化合物：其中R1、R2、R3、R4、R5、R6、X和Y如本文所定义，是Bcl-2的抑制剂，并且对于治疗以异常细胞增殖和/或失调的细胞凋亡为特征的疾病是有用的。
• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。