| 1309454-10-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1309454-10-1
• 化学式: C₁₇H₃₀N₂O₇
• 分子量: 374.434
• InChiKey: XEEWZERHUVLRAR-SBXXRYSUSA-N

反应信息

• 作为反应物：
  描述：

  、 ATP 在 pantothenate kinase 、 dephosphocoenzyme A kinase 、 phosphopantetheine adenyltransferase 、 potassium chloride 、 magnesium chloride 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Insights into Protein-Protein and Enzyme-Substrate Interactions in Modular Polyketide Synthases

  摘要：

  Numerous natural products of clinical value are bio-synthesized by polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs), which are multienzymes comprising modules of catalytic domains. The key players in each module are carrier proteins, which serve as attachment points for the growing substrate chains. Thus, the details of carrier protein-based substrate delivery to each active site are central to understanding chain assembly in these systems. In the enterobactin NRPS, communication between a peptidyl carrier protein (PCP) and the adjacent thioesterase (TE) domain occurs through formation of a compact complex. Using NMR, we show that the corresponding interaction between a PKS acyl carrier protein (ACP) and its downstream TE is fundamentally different: chain transfer occurs in the absence of a protein-protein interface, with contact limited to the substrate acyl terminus.

  DOI：

  10.1016/j.chembiol.2010.05.017