9-Octadecenoic acid (9Z)-, dimer | 7049-68-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-Octadecenoic acid (9Z)-, dimer
• 英文别名: (Z)-octadec-9-enoic acid
• CAS: 7049-68-5
• 化学式: C36H68O4
• 分子量: 564.9
• InChiKey: YZAZXIUFBCPZGB-QZOPMXJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.22
• 重原子数：
  40
• 可旋转键数：
  30
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS<br/>[FR] PROMÉDICAMENTS LIPIDIQUES ORIENTANT VERS LE SYSTÈME LYMPHATIQUE
  申请人：ARIYA THERAPEUTICS INC

  公开号：WO2019046491A1

  公开（公告）日：2019-03-07

  The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.

  本发明提供了淋巴系统定向脂质前药，其制药组合物，制备这种前药和组合物的方法，以及改善作为脂质前药一部分的治疗剂的生物利用度或其他性质的方法。本发明还提供了治疗疾病、紊乱或症状的方法，包括向需要的患者施用所提供的脂质前药或其制药组合物。
• STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS
  申请人：HANSEN Christian

  公开号：US20110269675A1

  公开（公告）日：2011-11-03

  A method for the treatment and/or prophylaxis of an osteonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis, the method comprising administering an effective dose of a strontium-containing compound (a) to the mammal. A method for the treatment and/or prophylaxis of an osteonecrotic bone disease, such as, e.g., idiopathic or secondary osteonecrosis, avascular hone necrosis, glucocorticoid induced bone ischemia/osteonecrosis and femoral head necrosis, in a mammal who is to be or is treated with a therapeutic agent (b) known to or suspected of inducing apoptosis and/or necrosis of bone cells, the method comprising administering a strontium-containing compound (a) in combination with (b).

  一种用于治疗和/或预防哺乳动物中的骨坏死性骨病，例如特发性或继发性骨坏死、缺血性骨坏死、糖皮质激素诱导的骨缺血/骨坏死、Legg-Calve-Perthes病和股骨头坏死的方法，包括向哺乳动物投予有效剂量的含锶化合物（a）。一种用于治疗和/或预防骨坏死性骨病的方法，例如特发性或继发性骨坏死、缺血性骨坏死、糖皮质激素诱导的骨缺血/骨坏死和股骨头坏死，该方法适用于要或正在接受已知或疑似诱导骨细胞凋亡和/或坏死的治疗剂（b）的哺乳动物，包括同时投予含锶化合物（a）和（b）。
• COMPOUNDS AND METHODS OF TREATING OBESITY
  申请人：Katzhendler Jehoshua

  公开号：US20110178151A1

  公开（公告）日：2011-07-21

  The present invention relates to novel fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as agents for the treatment of obesity and related disorders, and for improving cognition.

  本发明涉及一种新型脂肪酸衍生物、其制备方法、包括这些化合物的制药组合物，以及使用这些化合物和组合物的方法，特别是作为治疗肥胖和相关疾病的药物和改善认知能力的药物。
• HYDROXY- AND ALDEHYDE FUNCTIONAL COMPOUNDS
  申请人：Meier Michael A.R.

  公开号：US20110198535A1

  公开（公告）日：2011-08-18

  The invention relates to a method for producing a mixture containing hydroxy- and aldehyde functional compounds by a cross-metathesis reaction of at least one at least monounsaturated fatty acid or at least one at least monounsaturated fatty acid derivative with an olefinic compound having at least one hydroxy group and at least one C—C double bond, in the presence of a metathesis catalyst at a maximum temperature of 180° C.

  本发明涉及一种方法，通过交叉烯烃反应，在至多180°C的最高温度下，将至少一种至少单不饱和脂肪酸或至少一种至少单不饱和脂肪酸衍生物与至少一种具有至少一个羟基和至少一个C-C双键的烯烃化合物在存在烯烃交换催化剂的情况下反应，以产生含有羟基和醛基官能团的混合物。
• METHOD FOR PRODUCING ALDEHYDE FUNCTIONAL COMPOUNDS
  申请人：Meier Michael A.R.

  公开号：US20120022276A1

  公开（公告）日：2012-01-26

  The invention relates to a method for producing aldehyde functional compounds by a cross-metathesis reaction of an olefinic compound having at least one hydroxy group and at least one C—C double bond with at least one at least monounsaturated fatty acid or at least one at least monounsaturated fatty acid derivative, in the presence of a metathesis catalyst at a maximum temperature of 180° C. and in the presence of at least one reagent that acts as a protective group-forming compound in relation to the aldehyde group of the aldehyde functional compounds.

  本发明涉及一种方法，通过交叉烯烃反应，在存在最高温度为180℃的交换催化剂和至少一种至少单不饱和脂肪酸或至少一种至少单不饱和脂肪酸衍生物的情况下，将至少具有一个羟基和至少一个C-C双键的烯烃化合物与其反应，形成醛官能团化合物，并在至少存在一种作为保护基形成化合物相对于醛基的试剂的情况下进行。