Methyl 2-[3-cyano-4-(trifluoromethylsulfonyloxy)phenyl]-1,3-thiazole-5-carboxylate | 934470-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Methyl 2-[3-cyano-4-(trifluoromethylsulfonyloxy)phenyl]-1,3-thiazole-5-carboxylate
• CAS: 934470-45-8
• 化学式: C₁₃H₇F₃N₂O₅S₂
• 分子量: 392.336
• InChiKey: COQYHEWOKWQBHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  143
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• TRIARYLCARBOXYLIC ACID DERIVATIVE
  申请人：Astellas Pharma Inc.

  公开号：EP1932832A1

  公开（公告）日：2008-06-18

  It is intended to provide an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on which has a non-nucleic acid structure and exerts an excellent xanthine oxidase inhibiting action and a hypouricemic effect. It has been confirmed that a novel triarylcarboxylic acid derivative, which is characterized by having a carboxyl-substituted heteroaryl group and an aromatic ring group such as a phenyl group attached in para-position on a benzene ring and further carrying a cyano group on the same benzene ring, has a potent xanthine oxidase inhibiting action and a hypouricemic effect. Thus, it is found out that this compound is appropriately usable as an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on.

  本发明旨在提供一种用于治疗或预防高尿酸血症、痛风、炎症性肠病、糖尿病肾病、糖尿病视网膜病变等的药剂，该药剂具有非核酸结构，可发挥出色的黄嘌呤氧化酶抑制作用和降尿酸作用。研究证实，一种新型三芳基羧酸衍生物具有强效的黄嘌呤氧化酶抑制作用和降尿酸作用，该衍生物的特征是具有一个羧基取代的杂芳基和一个芳香环基，如苯环上对位连接的苯基，并在同一苯环上进一步带有一个氰基。因此，该化合物可用于治疗或预防高尿酸血症、痛风、炎症性肠病、糖尿病肾病、糖尿病视网膜病变等。
• EP1992361A1
  申请人：——

  公开号：EP1992361A1

  公开（公告）日：2008-11-19
• US8426453B2
  申请人：——

  公开号：US8426453B2

  公开（公告）日：2013-04-23